Posted by KaraS on November 13, 2004, at 23:23:09
In reply to CCK sulfated/unsulfated..dopamine/CCK autoreceptor, posted by tealady on November 13, 2004, at 21:31:18
>
>
> CCK is involved. Actually as with everything, it seems involved in a lot of things
> somehow having sufficient sulfates maybe effects this
>
> http://psychologytoday.psychtests.com/articles/mentalhealth/pd_cckcl.html
> Mental Health Articles: Panic Disorder and Agoraphobia
> CCK coexists and interacts with other neurotransmitters. It is colocalized and/or interacts with norepinephrine, serotonin, dopamine, GABA, acetylcholine and vasopressin
>
> I don't really understand any of this but maybe someone does...
>
> On dopamine autoreceptors...
> http://www.acnp.org/g4/GN401000020/CH020.html
> "In recent years, it has become apparent that we need to revise our concept of autoreceptors with respect to DA neurons. It has been demonstrated that the peptides cholecystokinin (CCK) and neurotensin are differentially colocalized with DA in subpopulations of midbrain DA neurons. These peptides can be released from the DA neuron and stimulate their specific receptors also located on the DA cell membrane. Thus, we now need to conceptualize DA neurons as possessing not only DA autoreceptors, but also CCK and neurotensin autoreceptors. Moreover, these peptides have the ability to modulate DA autoreceptor function."
>
> " Although not proof, these studies suggest that the effect of CCK on DA autoreceptor-mediated inhibition of impulse flow is due to a direct interaction with the DA cell membrane"
>
> "Unsulfated CCK and CCK tetrapeptide are selective CCK-B agonists, and they have been used to explore the question of which receptor subtype is associated with the modulatory effects of CCK on DA autoreceptor function"
Way over my head here but what I get from this is that sulfation may be a factor influencing certain peptides which effect the DA autoreceptors? I have been recently made aware of three other processes so far that may impact the sensitivity of these autoreceptors - though again they were all a bit out of my range of comprehension. I wonder what your post suggests (if anything) for treatment. Maybe Larry, Ray or JLx can help out here.Thanks for posting this!
Kara
poster:KaraS
thread:415630
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415656.html