Posted by tealady on November 22, 2004, at 18:24:17
In reply to Re: Calcium Citrate Malate..any biochemists??? » tealady, posted by KaraS on November 21, 2004, at 14:00:32
> > Regulation of AcetylCoA/Palmitate cycle
> > AcetylCoa carboxylase catayzes the first committed step in fatty acid synthesis, and regulation of this enyzme controls all remaining steps.
> >
> > (It is inactivated through phsosporylation by hormone-responsive protein kinases (see how hormones get in it?<g>) and activated thru dephosphorylation by insulin reponsive protein phosphatase..and insulin.)
> >
> > In addition, THE ENZYME has an absolute requirement for CITRATE. Not only is citrate the SOURCE of ACETYL CoA in the cytosol, it also SIGNALS the availability of ample supplies of OXALOACETATE, and therefore pyruvate
(If acetyl CoA were the signal, the carboxylase would be turned on when the liver is already flooded with fatty acids and rapidly oxidising them)
OK ...so is this a worry with taking citrate forms? I guess that's my question with all of this
(didn't do fatty acid synthesis in my course ..just carbs, glycolysis, citric acid cycle etc)
Just wondering if citrate..if it gets into the blood still as citrate..if it could cause this fatty acid synthesis to flood the liver?..and does this cause any of that "bad" oxidation?
Acetyl CoA is inhibited by malonyl synthase. and aslo inhibited by palmitoyl CoA so as to prevent the synthesis of fatty acids faster than they can be incorporated into triglycerides."
> Mc Gilvery Boichemistry A fuctional approach
>
> So in my words...not sure if just taking citrate has provide wrong signalling...not sure if taking malate as well would help balance or mke it worse either..is it as clear as mud to you too?Anyway..that's where the idea comes from for sure <grin>..that's what ya wanted to know , right?
> > Then on p733 it talks aboout Male sex pheromone.
> > quote" Early French romantic literature reports that a man can become irresistable to women if he wears a handkerchief with which he has previously rubbed his armpits while fully aroused. This belief may accout for the odd feature of male attire - the exposed breast pocket handkerchief"
> > OK, Its true, its there..I had to lighten it a little..it goes on to describe priapol..that's what is transported thru the blood and secreted in the armpits.."the alcohol has a musky odour"..then it goes on to talk about swine and concupiscent boars <grin>
> >
> > JanThe text went on to say how male pigs froth at the mouth (froth contained the priapol) and that truffles contain the same priapol too which is why pigs are attracted to them..didn't know that.
I guess at least human males don't froth at the mouth ...but I'd be REAL wary of any that did <g>
> >
>
> Very, very complicated. Not clear as mud to me at all. I think I'll leave it that there may be some synergism by using citrate and malate together. From now on, however, I will make sure to avoid men with exposed breast pocket handkerchiefs. :-)
>
> Thanks for doing the research.
> K
>Umm just how transparent is your mud over there?
Jan
poster:tealady
thread:418339
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/419081.html