Posted by raybakes on November 23, 2004, at 8:58:38
In reply to Why does niacin make me wired?, posted by gromit on November 18, 2004, at 19:36:08
> My doctor suggested I try niacin to lower my high cholestrol. I took 500 mg a couple nights ago and couldn't sleep a wink. I took my trazodone with a little melatonin and a valerian root mixture. Usually this will knock me out, but I was up all night. I had a beer and when that didn't work either I had some shots of vodka.
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> I remember talking with Larry about NADH and how it only worked for a couple days. I remember now that I was taking niacin at that time but stopped because of the flush. I have read that the no-flush niacin does nothing for cholesterol and the time release stuff may be bad for you liver.
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> Any ideas?
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> Thanks
> Rick
>Hi Rick,
Came across this theory on niacin toxicity
'Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy.'
"It is proposed that this hepatotoxicity reflects the high demand for methyl groups imposed by niacin catabolism, leading to a reduction in hepatic levels of S-adenosylmethionine"
As homocysteine is excitotoxic, if this theory is correct, then you might feel wired.
Ray
poster:raybakes
thread:417660
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/419261.html