Posted by Larry Hoover on November 30, 2004, at 12:07:26
In reply to Larry-question about St. Johns Wort interaction, posted by TenMan on November 30, 2004, at 0:58:19
> Larry, in your opinion do you think that there would be a significant interaction between testosterone therapy (the patch form) and St. Johns Wort due to hepatic enzyme induction?
>
> Thanks much.SJW would reduce the effectiveness of testosterone supps, but I don't think the reduction would be dramatic. Testosterone is mostly bound while circulating in blood, which is to say, it attaches to carrier proteins. Free testosterone only has a half-life of something like twenty minutes, so the big thing is to pump up the bound testosterone levels. Reducing the free half-life from twenty minutes, to say fifteen minutes, is probably not going to be a big deal because the patches supply such a large dose (relative to pre-supplemented testicular output).
Milk thistle inhibits 3A4. Topamax induces it. These things go on all the time, and no one is much the wiser.
Lar
poster:Larry Hoover
thread:422170
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/422373.html