Posted by Larry Hoover on November 30, 2004, at 12:11:51
In reply to Re: fatigue and interleukin 6, posted by TenMan on November 30, 2004, at 10:25:37
> \
> > St. John's Wort also antagonises the effects of IL-6.
>
>
> I was just about to post the same thing on my St. Johns Wort question thread to Larry.
>
> I found this study last night along with an older one.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15303261
>
> I can't tell it the study implies the doses needed for this is very large or if a normal dose will do the trick. Maybe you can have a look?I'm a little surprised that an inhibitor that is active at picomolar concentrations does not have activity at normal physiological concentration as from typical treatment doses.
From looking at the history of this research team, they've shown that IL-6 release is inhibited by SJW extracts in vitro, and they further narrowed that activity down to the hyperforin content. It does no look like they've shown that IL-6 will actually be inhibited from normal oral dosing. It's pretty strongly suggestive, though.
Lar
poster:Larry Hoover
thread:421739
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/422374.html