Posted by KaraS on December 21, 2004, at 22:40:17
In reply to Re: Naturally modifying MAO-B, posted by linkadge on December 21, 2004, at 20:01:38
> MAO-B acts to metabolize primarily dopamine, and norepinephrine, whereas MAO-A acts to metabolize serotonin, and norepinephrine (a bit of overlap)
>
> Anyhow, if the herb acts to inhibit MAO-B only, then I would likely get a boost in norepinephrine and dopamine. However, it it inhibits MAO-A as well then it could drive serotonin levels too high and create serotonin syndrome. This is why they say not to combine SSRI's with MAOI's. However this restriction does not apply to selective MAO-B inhibitors like L-deprenyl.
>
> Linkadge
Just wanted to add that L-deprenyl is only selective for MAO-B in dosages of 10 mg. or less.
poster:KaraS
thread:432469
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/432677.html