Posted by lotus on April 30, 2005, at 14:18:42
In reply to Re: Also found this:science jargon:Translation Larry?, posted by KaraS on April 30, 2005, at 1:39:27
> > Maybe it's an inhibitor of both,I found this:
> > Being a safe and effective (albeit mild) MAOI, GH3 can be expected to help raise dopamine, noradrenalin, and serotonin through inhibition of their neuronal MAO destruction, with consequent antidepressant effect.
> >
> > "
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> If it inhibited MAO-A then I would think you'd have to follow the diet.
>
> HOW DOES GH3 INHIBIT MAO AS COMPARED TO CLASSICAL MAO INHIBITORS?
Classical MAO inhibitor drugs used in psychiatry (Parnate, Nardil) reduce depression by forming strong covalent bonds with the MAO. In a sense, they form a shell around the MAO and completely disable it. This reduces the metabolism of the serotonin and noreprinepherine but also can be dangerous, since it disables the MAO from performing its other functions. Tyramine is a substrate of MAO (that is, the MAO is there to metabolize it.) Tyramine is present in fermented foods including yogurt and fermented cheeses, as well as in pickles, shellfish and certain wines. If unchecked, it can lead to dangerously high blood pressure. The classical MAO inhibitors stop the metabolization of neurotransmitters but also keep the MAO from doing its job regarding tyramine. Many people on these anti-depressants died before the tyramine effect was understood. Currently, people taking them are on severe dietary restrictions. In contrast, GH3 "gets between" the MAO and the neurotransmitters (according to many researchers) and thus prevents the metabolization of the neurotransmitters. Under demand, such as stress or the presence of tyramine, the GH3 gets out of the way so the MAO can do its job. Once again, the same function is accomplished but with complete safety.
poster:lotus
thread:491319
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/491931.html