Posted by cache-monkey on May 9, 2005, at 14:06:16
In reply to Re: Niacinamide is great, but: Dependence? Withdrawal?, posted by Declan on May 9, 2005, at 1:35:34
Hey Declan,
Hmm. I had figured that part of the process of tapering a benzo is allowing your GABA-A receptors to go back to normal somehow. I.e. chronic benzo use down-regulates that receptors. The fact that they up-regulate slowly after cutting back on the benzo leads to the withdrawal symptoms.
Since niacinamide acts like a benzo at the receptors, I'd imagine it a) provides temporary relief from the symptoms, but b) slows down the process of up-regulation further.
Just my thinking on it...
~cache-monkey
> Hi CM
> I thought the fact that niacinamide hits the same receptors as benzos *is* the reason it would be useful when tapering. And if you ended up just as addicted/dependant? Its hard to imagine, if only because its going to be less effective. Once I discontinued 1600mg/d SAMe and had a noticeable withdrawal type feeling, but I'm sure it was nothing like wd from SSRIs. Not the same, but still....
> Declan
poster:cache-monkey
thread:485434
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/495602.html