Posted by Chairman_MAO on September 27, 2005, at 22:09:51
In reply to Want off Klonopin! gaba,niacin,inistol,theanine?, posted by qbsbrown on September 22, 2005, at 13:11:57
The Himalaya Herbals preparation Mentat/MindCare has been shown in studies to mitigate benzodiazepine withdrawal symptoms. After reading about this formulation, I am going to abandon ordering herbs from beyond-a-century and try using this. I am very impressed with their product line thusfar.
Prevention by BR-16A of GABA/BZ Receptor Mediated Triazolam withdrawal Reaction in Mice
Kulkarni, S.K., Sharma, D.K. and George, B. Pharmacology Division, University Institute of Pharmaceutical Science, Panjab University, Chandigarh, India.
ABSTRACT
Withdrawal from chronic treatment with triazolam (0.1, 0.25 and 0.5 mg/kg) i. p. once daily for 9 days followed by 24 hours withdrawal) produced hyperlocomotion increase in total activity and anxiety response when mice were tested using mini activity meter or on elevated plus-maze, respectively. Concomitant administration of trimazenil [Ro15-1788] (1 mg/kg i.p for 9 days) or BR-16A, a herbal psychotropic preparation (100 mg/kg, po. for 9 days) prevented the development of withdrawal-induced anxiety response. Withdrawal from chronic treatment with triazolam had no significant effect on learning and memory parameters as studied by transfer latency. However, treatment with BR-16A prevented the delay in retrieval observed after chronic use of triazolam.Note an approx. conversion to human dose for mice is mouse dose * 0.08. Thus, that is 8mg/kg, or a very reasonable dose of Mentat. Give it a try; I believe int he ingredients. Let me know how it goes, I think I'm going to order some.
www.himalayausa.com. Product is called MindCare, mentat sometimes elsewhere.
poster:Chairman_MAO
thread:558144
URL: http://www.dr-bob.org/babble/alter/20050924/msgs/560418.html