Posted by nolvas on November 11, 2005, at 6:55:25
In reply to Is Uridine safe?, posted by RedSoxFan79 on November 10, 2005, at 16:24:58
This is the study you are referring to? (see below) It doesn't mention dosage, and was used in conjunction with Omega 3 Fatty acids. I haven't seen any safety issues raised, maybe uridine is unsafe at a certain dosage or a different form of uridine is unsafe? Since the study doesn't give any information of dosage I would find it hard to supplement with Uridine until I knew the dosage levels. It's also not available as a supplement yet so maybe you have an alternative source?
Carlezon, W. A., Jr., et al. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry. 57(4):343-350, 2005.Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.
Brain phospholipid metabolism and membrane fluidity may be involved in the pathophysiology of mood disorders. The authors demonstrated previously that cytidine, which increases phospholipid synthesis, has antidepressant-
like effects in the forced swim test (FST) in rats, a model used in depression research. Because cytidine and uridine both stimulate synthesis of cytidine 5'-diphosphocholine (CDP-choline, a critical substrate for phospholipid synthesis), the authors examined whether uridine would also produce antidepressant-like effects in rats. They also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine. The authors first examined the effects of uridine injections alone and dietary supplementation with OMG alone in the FST. They then combined sub-
effective treatment regimens of uridine and OMG to determine whether these agents would be more effective if administered together. Uridine dose-dependently reduced immobility in the FST, an antidepressant-like effect. Dietary supplementation with omega-3 fatty acids reduced immobility when given for 30 days, but not for 3 or 10 days. A sub-effective dose of uridine reduced immobility in rats given sub-effective dietary supplementation with Uridine and OMG each have antidepressant-like effects in rats. Less of each agent is required for effectiveness when the treatments are administered together.http://www.nvo.com/shildtfinancial/sv003data/view.nhtml?profile=sv003data&UID=12547
poster:nolvas
thread:577513
URL: http://www.dr-bob.org/babble/alter/20051025/msgs/577676.html