Posted by linkadge on January 23, 2006, at 15:16:35
In reply to Re: Pycnogenol..mechanism for ADD depression?, posted by JayDee on January 20, 2006, at 1:18:04
I think that MAO-A preferentially metabolizes serotonin and norepinephrine, and that MAO-B preferentially metabolizes PEA, but both MAO-A and MAO-B metabolize dopamine.
http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=03/72055.030904&ELEMENT_SET=DECL"MAO also plays an essential role in the oxidative deamination of biogenic and food-derived amines, both in the central nervous system and in peripheral tissues. MAO is found in two functional isoenzyme forms, MAO-A and MAO-B, each of which shows preferential affinity for substrates and specificity toward inhibitors. Thus, MAO-A preferentially oxidizes serotonin, noradrenaline and adrenaline, whereas MAO-B preferentially metabolizes phenylethylamine. Dopamine is a substrate for both forms of the enzyme (Szelenyi, I.). "
Also see:http://biopsychiatry.com/mao.html
Linkadge
poster:linkadge
thread:599300
URL: http://www.dr-bob.org/babble/alter/20051208/msgs/602111.html