Posted by aeon on November 21, 2006, at 5:46:35
I am trying some vitex (chaste berry) to see if it can give me the much needed dopamine boost I so desperately lack. Anyone have experience with it? Specifically in comboith parnate?
The pharmacological effects of an ethanolic extract of vitex was studied regarding its effects on dopamine-D2 and opioid (mu and kappa subtype) receptors.(21) A relative potent binding inhibition was observed for dopamine-D2 and the opioid receptors. Binding to the histamine-H1, benzodiazepine, OFQ receptor, and the binding-site of the serotonin (5-HT) transporter, was significantly inhibited. The lipophilic fractions of the vitex extract contained the diterpenes which exhibited inhibitory actions on dopamine-D2 receptor binding. While binding inhibition to mu and kappa opioid receptors was most pronounced in lipophilic fractions, binding to delta opioid receptors was inhibited mainly by an aqueous fraction. The authors concluded that the data indicates a dopaminergic effect of vitex extracts and suggests additional pharmacological actions via opioid receptors. Due to this dopaminergic activity, it has been postulated that chasteberry may be used in the management of Parkinson’s disease, although no clinical research has been performed to support that theory.(22)
http://content.nhiondemand.com/moh/media/monoHerb.asp?ctype=ds&mtyp=1&objID=100046
poster:aeon
thread:705739
URL: http://www.dr-bob.org/babble/alter/20061118/msgs/705739.html