Posted by Tomatheus on December 1, 2006, at 22:06:07
In reply to Re: A new experience - happiness!, posted by aeon on November 26, 2006, at 17:39:34
Aeon,
Thank you for your responses. I appreciate the helpful information that you've provided.
Between quercetin, fish oil (including supplements with a high EPA-DHA ratio), and evening primrose oil, the only thing that seems to do anything for my depressive disorder is the evening primrose oil. If I take enough EPO (2,000-3,000 mg worth), I usually notice a moderate antidepressant response that lasts maybe 2-3 days before it fades away entirely. However, I think that it's also worth pointing out that my disorder is extremely treatment resistant (which is probably due to the fact that it includes both an atypical/anergic component and a melancholic/anxious component -- possibly caused by two separate biochemical abnormalities, if my suspicions are correct). My guess is that most individuals with classic cases of either melancholic depression or atypical depression will probably respond to supplements such as evening primrose oil, fish oil, and quercetin in a more consistent manner -- whether their response is positive, negative, or neutral.
With respect to the quercetin, I think that my non-response to it may be due to the fact that the supplement that I've been taking (the Vitamin World brand) just contains regular quercetin, as opposed to isoquercitrin (quercetin-3-0-glucoside). I'm considering ordering a quercetin supplement from Europe that purports to include isoquercitrin, a form of quercetin that (as you mentioned) is believed to be absorbed more efficiently by the small intestine than the regular form. I live in the U.S. and can't seem to find any quercetin products here that contain even a trace of isoquercitrin. Of course, it might be the case that I won't respond favorably (or at all, as the case seems to be) to any quercetin supplement, no matter how much I take and no matter what form it comes in. And considering that I'm currently trying a different treatment strategy, I won't be ordering the special European quercetin just yet -- if I even end up ordering it at all.
But if my current treatment strategy doesn't work out, I may give the isoquercitrin-containing quercetin supplement a try.
Thanks again for the information.
Tomatheus
> 1) What brand of quercetin do you take? Its a practitioner brand in australia called orthoplex.
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> 2) Do you think that a quercetin supplement with isoquercitin (quercetin-3-0-glucoside) would be any more potent than one without isoquercitin? Yes, maybe. I think from memory this is the compound that is formed in first pass metabolism of quercetin, and is easier to absorb. I can't get any here though so can't tell you from experience.
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> 3) Which symptoms of your illness have you found quercetin to be the most effective at relieving? Do you find quercetin to be energizing, anxiety-reducing, or both? Find it calming mostly. It seems to be a good mood stabiliser for me, and also stops my body from aching, and my tooth from swelling. In terms of mood though see my new thread about anandamide - this is better so far.
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> 4. 4) Finally, what have you found to be the best sources of EPA and GLA? Nordic naturals makes a pharmaceutical grade high EPA fish oil with borage oil in also. Very nice. Sometimes I use cold pressed EPO which is quite cheap.
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> Quercetin has a 24 hr half life and a great deal of it is absorbed in the end of the small intestine so it acts for a fair amount of time.
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> Cheers
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> aeon
>
>
poster:Tomatheus
thread:704435
URL: http://www.dr-bob.org/babble/alter/20061118/msgs/709555.html