Posted by Larry Hoover on July 31, 2007, at 10:51:04
In reply to reply to Larry, and How much zinc is toxic?, posted by Penlady on July 21, 2007, at 13:06:01
>
> Larry said "I'm not convinced that pyrroluria is a real disorder. I'll check the mineral ratios soon. I'm off to bed now, and I have a busy couple of days ahead.
> Lar"
>
> I wish I could convince you there is such a thing.Well, I'm accepting of the possible consequence of excreting pyrroles and thereby losing zinc in urine. My skepticism is with the broader syndrome that is collected under the rubric "pyroluria" (sic). Notwithstanding my concerns, this is still a nice article: http://www.kryptopyrrole.com/
> I thought I was having a nervous breakdown,was having personality changes, then started looking for answers, and realized that everyone in my family has the symptoms of Pyroluria, such as becoming more of a loner when getting older, anxiety,great internal tension, problems with sugar metabolism, allergies, no desire for breakfast, light sensitivity, loud noise sensitivity, poor ability to cope with stress, personality changes during prolonged periods of stress, inability to tolerate prescription medicine, depression that makes events look catastrophic.
Whoa! Have you been observing me? <Spock eyebrow>
> Within 3 days of taking B6 and zinc, my old personality was back, with only occasional anxiety because of the amount of stress our whole family is under. My mother also took the vitamins and felt IMMEDIATE relief. I am still trying to talk my brother into it, and I wonder how different many of our family member's lives could have been without the horrid depression and hermit-like behavior that ruined a good, useful life.
HIgh stress reactivity is a bitch.
> I am looking everywhere and can't find the answer to this. I keep getting told that too much zinc can throw off the other minerals in your body and can cause serious side effects. I am wondering how much zinc is too much, and I am hoping I can raise my zinc and B6 for more relief. Any ideas would be appreciated.
> PenladyWell, I can certainly help you with this concern.
High zinc intake will inhibit copper uptake from the gut. Both minerals are absorbed only from their salts (i.e. the soluble forms, not the elemental mineral). The copper storage disease, Wilson's disease (analogous to iron and hemachromatosis), is treated with high zinc intake. It is generally accepted that significant inhibition of copper uptake begins around about 80 mg/day zinc. Full blockade probably requires closer to 150 or 200 mg/day. You can probably safely take 50 mg/day zinc, without concern about copper.
Give your body a chance to adapt to the higher zinc levels. There are four transporters that we know of, that pump zinc from the gut (one of which is really an iron transporter, so iron deficiency anemia might be a long-term concern), and yours might be highly upregulated.
I know I've got a zinc problem, but I always assumed it was an uptake issue. Maybe it's at the other end of the stream.
Lar
poster:Larry Hoover
thread:498689
URL: http://www.dr-bob.org/babble/alter/20070601/msgs/773068.html