Posted by qqqsimmons on August 19, 2007, at 18:27:16
In reply to Re: zinc stimulant effect?, posted by Netch on August 16, 2007, at 8:21:54
thanks, you guys rule...here's an abstract for those interested:
Zinc and depression. An update.
Nowak G, Szewczyk B, Pilc A.
Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland. nowak@if-pan.krakow.plUnsatisfactory clinical efficacy and a variety of adverse effects of current antidepressant drugs have incited search for better therapy. Zinc, an antagonist of the glutamate/N-methyl-D-aspartate (NMDA) receptor, exhibits antidepressant-like activity in rodent tests/models of depression. Similarly to antidepressants, zinc induces brain derived neurotrophic factor (BDNF) gene expression and increases level of synaptic pool of zinc in the hippocampus. Clinical observations demonstrated serum hypozincemia in depression, which was normalized by effective antidepressant treatment. Moreover, our preliminary clinical study demonstrated the benefit of zinc supplementation in antidepressant therapy. All the data indicate the important role of zinc homeostasis in psychopathology and therapy of depression and potential clinical antidepressant activity of this ion.
poster:qqqsimmons
thread:774682
URL: http://www.dr-bob.org/babble/alter/20070816/msgs/777139.html