Posted by bleauberry on January 2, 2008, at 19:15:16
In reply to Are dopaminergic herbs really any safer than meds?, posted by clipper40 on January 2, 2008, at 3:28:57
The whole dopamine thing is so complicated it is way beyond the understanding of humans on earth. Best guess is that if receptors are either hyposensitive or hypersensitive then there will be problems, and that a drug will cause opposite effects in people depending on the condition of those receptors. For example, ritalin will send some people through the roof with energy and euphoria and maybe psychosis, and yet will totally calm someone else down and maybe even put them to sleep. Dopamine aint simple.
As for conversion from L-Dopa to dopamine to norepinephrine, that too is way complicated. There are all sorts of roadblocks along the way. There are enzymes that control those conversions. There are feedback loops. There is the interplay of hormones like cortisol an thyroid. There are instructions from genetics, pituitary and hypothalamus. One person for example could get increasing dopamine effects with each 1000mg dose of tyrosine they take, while someone else will max out at 1000mg no matter how much more they take.
I am like you and many others here in that I try to analyze in detail how something works so I will know if maybe that is what I need. It just aint that easy. Some things that made perfect sense were horrible. Other things that made no sense at all were a surprise.
Dopamine drugs, and most psych drugs, are tested for what, maybe 6 weeks, 8 weeks, 12 weeks. And in rare cases they have 52 week trials. As most of us need to be on something for years or forever, they just haven't studied what the drugs do to the brain or body in that timeframe. I think we all know from personal experience and anecdotal evidence that dramatic changes do occur, and some of them are either longlasting or permanent, even months or years after withdrawing from the substance.
I used to think herbs were safer than drugs. I now see them as being equal in safety, or danger, but that the drugs are more concentrated, more single actioned, and more powerful. Personally I do give any herb the same respect I give a prescription med.
Basically I think messing with dopamine is absolutely crucial for recovery, and yet very risky at the same time. Whether it be pharmaceutical or herbal. I think the safest place to look is with things that not only help dopamine function, but that also offer neuroprotection at the same time.
poster:bleauberry
thread:803733
URL: http://www.dr-bob.org/babble/alter/20071031/msgs/803860.html