Posted by cache-monkey on January 29, 2008, at 15:17:18
In reply to Re: Yuck » nolvas, posted by linkadge on December 16, 2007, at 20:54:40
> Yeah thats strange seeing as it is marketed for achohol withdrawl.
>
> LinkadgeThe effects of another BZD antagonist, flumazenil, on anxiety are mixed. I've seen a study showing that it potentially exacerbates anxiety in panic disorder and another one that shows anxiolytic effects in high state-anxiety and anxiogenic effects in low state-anxiety.
The latter paper argues that it "normalizes" BZD receptor function, "returning it to a baseline state". This, I think, is why it has been useful for certain aspects of alchohol and BZD withdrawal. If given before withdrawal, it increases the sensitivity of sub-sensitized receptors, reducing tolerance. If given after BZD withdrawal there are transient negative effects (dizziness, lightheadedness) during administration, but medium-run positive effects on anxiety.
So maybe this has something to do with your BZD receptors being in an irregular conformation. Have you been on BZDs in the past?
Or maybe it has to do with 5-HT1 agonism? Also, while the main isoflavoinoid (puerarin) antagonizes the 5-HT2A/C receptors, who knows about the other constituents.
Let us know if you try kudzu again.
Best,
cache-monkey
poster:cache-monkey
thread:794673
URL: http://www.dr-bob.org/babble/alter/20080110/msgs/809578.html