Posted by nolvas on June 20, 2009, at 10:09:49
In reply to Re: Bad reaction to Taurine and N-Acetylcysteine, posted by mogger on June 19, 2009, at 20:36:13
You seem to mostly be trying supplements that influence GABA. Everything that positively affects GABA to produce an anxiolytic effect will usually only be a short term solution to anxiety. I would look at a completely different method of influencing anxiety. BDNF (Brain Derived Neurotrophic Factor) is implicated in anxiety and depression, whilst we know quite a lot about the brain we are at least I believe quite a long way from determining all the factors that produce depression and anxiety. Also we will find genetic variances which cause some people to be almost immune to anxiety and depression and others to be quivering wrecks. If you have bad genetics then that's life but you can positively influence your state with the right nutrients etc.
"Numerous studies have demonstrated that curcumin, amongst only a few other things such as high impact exercise, learning, bright light, and antidepressant usage, has a positive effect on neurogenesis in the hippocampus and concentrations of brain-derived neurotrophic factor (BDNF), reductions in both of which are associated with stress, depression, and anxiety.[24][25][26]"
Source : Wikipedia > keyword : BDNF
http://www.imhro.org/sponsored-scientists/francis-lee.html
So if you wish to go down the route of increasing neurogenesis in the brain and increase BDNF then there are some things you can try.The first is the most difficult :
1. Exercise
2. Take the most bioavailable Curcumin you can find.
3. Eat lots of blueberries"The great news is that BDNF levels can be naturally boosted. Aerobic exercise boosts BDNF. The most important nutrient that helps is pantethine, providing the needed basic compound (cysteamine) that nerve cells need in order to make BDNF. Nutrients that also help make BDNF or protect it from declining are acetyl-l-carnitine, fish oil, blueberries, and curcumin."
Source : https://www.als.net/forum/Default.aspx?g=posts&t=46912
I can't guarantee that the above information will reduce your anxiety, however exercise and blueberries certainly shouldn't decrease your health, and curcumin has other benefits in reducing pain and inflammation. The other nutrients mentioned above are certainly good for health, acetyl l-carnitine must be used wisely at certain dosages it reduces anxiety and at larger doses it can increase anxiety.Good luck with whatever you try.
Some references :
Effect of intraperitoneal acetyl l carnitine on anxiety-like behaviours in rats.
Int J Neuropsychopharmacol. 2004 Sep 20:1-10
Acetyl-L-carnitine is an acetyl derivative of carnitine, an endogenous molecule synthesized in vivo and supplemented by diet (mainly via meat and dairy products). Several parallel, double-blind, placebo-controlled studies have demonstrated that Acetyl-L-carnitine treatment produces beneficial effects in geriatric depression. Since most antidepressants also have anti-anxiety effects we examined whether Acetyl-L-carnitine shows anti-anxiety effects in a rat model of anxiety. Compared to a saline-injected control group, chronic administration of Acetyl-L-carnitine at doses of 10 and 100 mgkg (tested 24 h after the last dose administration) showed no effects, whereas doses of 50 and 75 mgkg significantly reduced anxiety-like behaviours in the elevated plus-maze. Acute Acetyl-L-carnitine (100 mgkg), on the other hand (tested 6 h after administration), demonstrated anxiogenic effects. Our data suggest that chronic Acetyl-L-carnitine administration may produce an inverted U-shaped curve of dose-dependent changes in anxiety-like behaviour. The precise mechanism by which Acetyl-L-carnitine decreases anxiety-like behaviour after peripheral administration remains to be determined.
poster:nolvas
thread:899687
URL: http://www.dr-bob.org/babble/alter/20090410/msgs/902240.html