Posted by Trotter on December 16, 2012, at 3:50:10
Thought I might share some of my recent research.
High fat diet increases translocation of LPS (endotoxaemia) and lowers bifidobacteria.
http://www.ncbi.nlm.nih.gov/pubmed/17823788High fat diet increased intestinal permeability.
http://www.ncbi.nlm.nih.gov/pubmed/18305141High fat diet decreased bifidobacteria and increased LPS shedding gram negative bacteria.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200004&lng=en&nrm=iso&tlng=enVery strong link between both translocation of LPS and intestinal permeability and major depression.
http://www.ncbi.nlm.nih.gov/pubmed/18283240High fat diet directly linked to depression in mice.
http://psychcentral.com/news/2012/05/28/high-fat-diet-linked-to-depression-anxiety-in-mice/39295.htmlHigh fat diet caused changes in the brains of mice causing depressive symptoms
http://www.sciencedaily.com/releases/2012/12/121212092104.htmCorelation between high fat diet and depressed humans.
http://www.livestrong.com/article/436309-why-fatty-foods-make-people-feel-depressed/Translocation of LPS caused by high fat diet was reversed by FOS, possibly due to increase in bifidobacteria.
http://www.ncbi.nlm.nih.gov/pubmed/17823788Hypothesis:
I think a high fat diet promotes 'bad' bacteria in the bowel and inhibits 'good' bacteria such as bifidobacteria. The bad bacteria cause 'leaky gut' and allow LPS to cross the bowel/blood barrier. This translocation of LPS provokes an immune response, triggering the release of pro-inflammatory cytokines which travel to the brain and cause brain fog and depression.Consuming a bifidobacterial probiotic such as Align, and/or taking a pro-bifido prebiotic such as Bimuno may reduce bad bacteria, repair the leaky gut and inhibit the translocation of LPS, leading to a reduction in brain fog and depression. Of course reducing fat in the diet would also be a good idea.
poster:Trotter
thread:1033095
URL: http://www.dr-bob.org/babble/alter/20120530/msgs/1033095.html