Posted by Larry Hoover on January 27, 2016, at 18:14:47
In reply to methylcobolamine vs. cyanocobolamine, posted by linkadge on January 26, 2016, at 15:25:24
> Has anyone had improved reaction to the "activated" form of B12 (methlycobolamine) vs. cyanocobolamine ?
>
> LinkadgeHey, Link. I hope you are well.
Cyanocobalamin is an artefact of early biochemistry. The first isolation of this molecule was with cyanide extraction. It is not the natural form of the molecule. In fact, I have read that the biochemical benefit of one molecule of cobalamin is exactly counteracted by the biochemical burden of neutralizing one molecule of cyanide. Net benefit zero. Other sources don't support the extent of the negative impact of the cyanide moiety, as it can also be neutralized by glutathione. But, ultimately, given that cyanocobalamin is not found in nature, why not take the natural form, methylcobalamin? It's not activated in any way; it's simply not combined with the negative impact of a cyanide molecule. Hydroxycobalamin is an equivalent natural form of B12.
Sublingual methylcobalamin is a very effective way to take this vitamin. If swallowed, it requires binding to an uptake transporter in the small intestine for absorption. Passing directly into the blood through the oral mucosa is more efficient.
Best,
Lar
poster:Larry Hoover
thread:1085725
URL: http://www.dr-bob.org/babble/alter/20150301/msgs/1085744.html