Posted by linkadge on December 3, 2017, at 13:07:45
In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by farshad on December 3, 2017, at 5:54:12
Oh I'm sorry. I am not a diagnostician, but you seem to want one who doesn't ask questions?
The MAO variants that are reported by common genetic tests are only weakly associated with functional brain MAO levels.
Also, in many cases, higher MAO levels are associated with depression and social stress induced anhedonia (remarkably reversed by MAO inhibitors).
Mood stabilizers (lithium, valproate) and other GSK3 inhibitors may increase monoamine oxidase levels, over time, through downstream interactions with per2.
However, genetic tests are only in their infancy. The actual functional level of brain serotonin depends on the activity of likely hundreds of receptors, enzymes, neurotransmitters etc. Tryptophan hydroxylase, SERT, 5-ht1a, 5-ht1b, GSK3, just to scratch the surface.
Also, increasing MAO-A may leave you with lower levels of norepinephrine and dopamine (in addition to serotonin) as this enzyme catabolizes all three.
Linkadge
poster:linkadge
thread:1096138
URL: http://www.dr-bob.org/babble/alter/20160521/msgs/1096159.html