Posted by Hugh on October 13, 2018, at 15:20:07
In reply to something for depression, estradiol?, posted by cadburyhesychasm on October 11, 2018, at 11:22:11
> Ideally, I want something with rapid effects that causes a sustained euphoria with stress-relief maybe increasing endorphins in a sustainable way.
Then try taking low-dose naltrexone (LDN). Start at a dose of 1.5 mg (taken at bedtime) and gradually increase your dose over several weeks until you're at the maximum -- 4.5 mg.
If low-dose naltrexone doesn't have the desired effect on you, then try an even lower dose of it. If that doesn't help, then go even lower. In fact, the lower the dose of naltrexone, the more effective it might be. The following quote is from
https://www.researchgate.net/publication/226113151_Ultra-Low
Dose_Naltrexone_Decreases_Dependence_and_Addictive_Properties_of_Opioids"Cotreatment with ultra-low-dose naltrexone at 16.7, 20, or 25 ng/kg, but not at 10 or 200 ng/kg, induced a significant CPP after this 2-h delay. This finding implies that, whereas the rewarding effects of morphine have dissipated by 120 min postinjection, ultra-low-dose naltrexone may extend this effect."
In other words, an extremely low dose of naltrexone enhanced the effects of morphine, and prevented tolerance to it from developing. And it prevented dependence and addiction from developing. A higher, but still tiny, dose of naltrexone didn't have these beneficial effects.
Even if you're not taking opioids, you might benefit from taking ultra-low-dose naltrexone, since we all have naturally occurring opioids -- endorphins. An extremely low dose of naltrexone, taken every day, might improve your brain's response to your naturally occurring endorphins.
So if you aren't helped by 1.5 to 4.5 milligrams of naltrexone, try lowering your dose to micrograms. If that doesn't help, lower your dose to nanograms. If that doesn't help, lower it to picograms. Other than the naltrexone, all you need is distilled water to dilute it with and a calculator.
Naltrexone is water-soluble, so dissolve a 50 mg tablet in 50 ml of distilled water and use a medicine dropper to measure the dose. If refrigerated, liquid low-dose naltrexone will keep for several weeks.
poster:Hugh
thread:1101309
URL: http://www.dr-bob.org/babble/alter/20180212/msgs/1101330.html