Posted by Phoenix1 on January 14, 2008, at 22:36:05 [reposted on January 16, 2008, at 2:37:27 | original URL]
In reply to , posted by on December 31, 1969, at 18:00:00
> Yep your wrong I can guarentee you yellow grapfruit juice increase's some benzo effects.
What am I wrong about? I agreed that grapefruit juice increases blood levels of some benzodiazepines. Like diazepam. That's a scientific fact. But it doesn't effect lorazepam in the slightest. That's also a scientific fact. Then I said I wasn't sure about temazepam and clonazepam. Someone else said temazepam (That's what you were asking about originally) wasn't affected by grapefruit, LarryHoover I believe. Then I made a joke that the placebo effect had been ruined. (The joke was emphasized by the ":)" smiley face symbol). Sorry if this offended you.
It looks like if a benzo is metabolized by the liver, via the CYP3A4 enzyme, then grapefruit will increase it's effects. If it is NOT CYP3A4 metabolized, then grapefruit juice will do absolutely nothing. Like in the case of Lorazepam, or Temazepam (The one you were interested in), grapefruit juice has no effect. So show me where I'm wrong. I'm always learning, and I think I summed this up correctly, but everyone makes mistakes, right?
Phoenix1
poster:Phoenix1
thread:806889
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/806912.html