Posted by desolationrower on August 20, 2008, at 0:46:02
In reply to nmda receptors, posted by englishman006 on August 19, 2008, at 2:42:02
NMDA antagonists are probably going to be more helpful in reducing fear as opposed to improving extinction. I think there is generally a trade-off on that. Look at the stuff on yohimbe: its panicogenic, but also facilitates extinction if used during exposure therapy.
http://cnsspectrums.com/aspx/articledetail.aspx?articleid=1153
is an interesting read. Note that there are several ways to antagonizise this receptor, and they can have different effects.Speculation: I wonder if NMDA agonists like moderate d-cycloserine, glycine, maybe some *racetams would be better for specific anxieties, and NMDA antagonists would be better for something like generalized social anxiety that have some unconditioned anxiogenic properties.
As for opioid tolerance, the thing with partial agonists is that a small amount will just add some agonism and a large amount will also block the regular activity.
poster:desolationrower
thread:847145
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/847296.html