Posted by linkadge on June 8, 2010, at 15:27:39 [reposted on June 11, 2010, at 14:14:48 | original URL]
In reply to Re: what does 5-ht7 antagonist mean/do????, posted by bleauberry on June 7, 2010, at 18:09:23
>line, we might be able to theorize what blocking >a 5ht7 receptor does, mechanically, maybe even >measure neurotransmitters as a result of it, and >such, but does that mean it is going to help >Jane or Joe or Sally?
Its a little more complicated than observing the behavioral effects of 5-ht7 antagonists in mice.
First off, with amisulpride, they can reverse the antidepressant effect with 5-ht7 agonists, but not dopamine agonists. Secondly, amisulpride augments the behavioral effects of SSRI's but not dopamine reuptake inhibitors. It augments hippocampal serotonin above that produced by SSRI treatment. Thirdly, augmentation of different neurotransmitter systems produces diverse behavioral effects (i.e. swimming vs. climbing). The AD effect of amisulpride is consistent with serotonergic augmentation. Fourthly, the antidepressant effect of amisulpride (and other selective 5-ht7 antagonists) is nonexistent in 5-ht7 null mice, who already exhibit a pattern of reduced REM behavior similar to mice administered 5-ht7 antagonists.
Linkadge
poster:linkadge
thread:950721
URL: http://www.dr-bob.org/babble/neuro/20100607/msgs/950728.html