Pristiq doesn't hit dopamine? wtf

Posted by Conundrum on September 23, 2010, at 0:29:58

Apparently pristiq doesn't really boost dopamine the way effexor does. This makes this me too drug even lamer than its predecessor. I guess it has less side effects, but I wonder how effective it will be in the long run, especially when dose escalations don't increase dopamine?
If you look closely at the following studies you will see that venlafaxines(effexor) Ki value for DAT is around 7000 nano mols.
Desvenlafaxine has a DAT Ki of 100 in the mirco mol range. So it actually has less effect on DA than venlafaxine! The DAT blocking effect must belong to one of the abandoned metabolites.
http://jpet.aspetjournals.org/content/318/2/657.full
http://www.nature.com/npp/journal/v25/n6/full/1395741a.html#tbl1
Oh Wyeth you've fooled everyone again, well almost everyone.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking Lamictal, mirtazapine.
Does humor belong in depression?

Thread

Pristiq doesn't hit dopamine? wtf Conundrum 9/23/10

Post a new follow-up

[963434]

Notify the administrators

Start a new thread

poster:Conundrum thread:963434
URL: http://www.dr-bob.org/babble/neuro/20100607/msgs/963434.html