Posted by djmmm on April 7, 2004, at 19:59:04
In reply to Re: conbining effexor, illegal drugs « PsychoSage, posted by Dr. Bob on April 4, 2004, at 18:16:03
> Posted by PsychoSage on April 3, 2004, at 11:00:34
>
> > The above statements are incorrect.
> >
> > A SSRI blocks the pathways that MDMA (ecstasy) uses for its actions on neurons.
> >
> > The effects of the ecstasy will be strongly diminished. Just a waste of your money.
>
> This is totally wrong. Effexor and methampehtamine is very toxic. Effexor and ecstacy will make you sick as a dog. Unless you are taking an eighth of a pill, then I think it's much more serious than this post suggests.
>
> A reuptake inhibitor and a serotonin agonist like ecstacy equals too much serotonin.
>
> It will not be as if you are taking a stimulant like meth and nullifying the effects with valium or ativan which is what is used in hospitals to reduce amphetamine intoxication.
>
> Otherwise, parents would put their kids on antidepressants before they went out, so their kids don't play with ecstacy.
>
> SSRIs are not like opiate-blockers for heroin addicts.
>
> SSRIs or an SNRI like effexor and E are not safe.
>
> E also greatly increases norepinephrine which effexor works on too.I have taken MDMA with SSRIs and Effexor...(a long time ago) From personal experience, after repeated or even acute exposure to SSRIs or atypical ad's like Effexor, your response to MDMA is severly diminished, and with the more selective SSRIs (Paxil, celexa) your MDMA experience is often completely attenuated.
MDMA works at the reuptake pumps...blocking these sites would naturally decrease the pumps exposure to MDMA. MDMA is less selective to serotonin then most SSRIs (supported by the use of the very unselective SSRI, Prozac)...this is based on years of studies.
I agree that the combination isn't safe, but the danger has probably more to do with blood pressure then serotonin syndrome.
poster:djmmm
thread:332028
URL: http://www.dr-bob.org/babble/subs/20040130/msgs/333852.html