Posted by Larry Hoover on June 7, 2005, at 18:43:46
In reply to Percocet without the acetaminaphen, posted by Carolannbirks on June 7, 2005, at 8:01:32
> A lot of the people who post on this board seem to be very familiar with medications such as opiate painrelievers, so I am hoping someone may know the answer to this.
>
> I have been prescribed Percocet for the past 7 years for chronic pain, I am concerned about the danger of the tylenol that is in it, using it every day 3 to 4 times a day. I know it can be organ toxic, but my doctor assures me that staying under 4000 mg of it a day will be safe.Just so you know, the reason that acetominophen can injure the liver is because it can use up all the glutathione, which is an antioxidant. If all the glutathione gets used up, the liver cell that doesn't have any left might commit a form of suicide, called apoptosis. Not good for the liver, in the long run, if a lot of the cells are doing that at the same time.
The treatment for that is N-acetyl cysteine (NAC). That's what they'd give someone at the emergency room who'd accidentally OD'd on tylenol. Couldn't hurt you to take some, if it would ease your own fears about liver stress. Available at any decent pharmacy or health food store.
> I would rather take the Percocet in a form that does NOT have the tylenol, but I dont care for time release drugs like Oxycontin. I am afraid of that.
Why would you be concerned about the -contin format? The suffix represents a pill that is designed to continually release the drug, but at a very slow rate, over a twelve hour period. So, a 10 mg Oxycontin is equivalent to two 5 mg Percocet in oxycodone dose, but you have less hassle, and a more stable blood concentration over the entire 12-hour period. It's easier to titrate the dose to the pain. If you require more than 50% of the Oxycontin dose in additional fast-acting meds for breakthrough pain over three successive dosing periods, you increase the Oxycontin dose by one increment at the next dosing interval.
> Sooooooooo, my question is does anyone know anything about a form of oxycodone called ROXICODONE that is supposed to be percocet without the tylenol? My doctor has never heard of it but I have researched it on the internet, and it apparently exists. What I don't know is, is this available in the US? Thanks anyone.
Yes, Roxicodone is available in the U.S. As are numerous other pure oxycodone hydrochloride products. Sometimes these are described as oxycodone IR (immediate release) to distinguish them from the XR (extended release) and -contin (continual release) formulations.
Your doctor can check for available formulations by searching the FDA Orange Book at:
http://www.fda.gov/cder/ob/default.htmOr, another way to find active products is to do a generic search at rxlist:
http://www.rxlist.com/Lar
poster:Larry Hoover
thread:508976
URL: http://www.dr-bob.org/babble/subs/20050602/msgs/509295.html