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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Greg on July 6, 2000, at 11:06:12
Cam,
I have been getting chronic nausea since being dianosed. My doc has given me a drug called Zofran for it. It's absolutely amazing! When the nausea hits, I take one and within 20-30 minutes the nausea is completely gone, everytime.
I know this *might* be out of your field of expertise, but I was wondering if you had any thoughts, theories or info as to why it is so effective?
The pills cost $19.50 each (US) so thank God for medical insurance.....
I hope everything is well with you and your family.
Greg
Posted by Cam W. on July 6, 2000, at 14:44:07
In reply to Cam - Zofran?, posted by Greg on July 6, 2000, at 11:06:12
Greg - I believe that Zofran is a selective serotonin-3 (5HT-3) antagonist. 5HT-3 receptors are mainly found in the small intestine (and in the CNS to a lesser degree). By blocking this receptor you decrease the nausea. The 5HT-3 receptor is responsible for the nausea seen as a start-up side effect of the SSRIs. Stimulation of the 5HT-3 receptor by the increased serotonin (as a result of the SSRI) causes nausea, which is resolved when this receptor is desensitized (usually within the first month after starting the SSRI). They use Zofran a lot after chemotherapy.
(If you want to have a little fun, ask your doc for Marinol for nausea. It is synthetic THC and has been described as smoking 100 joints at a time. The only problem with it is that it is terribly disorienting and doesn't work as well as Zofran. I thought that I would add this because you expect it from me). - Cam
Posted by SLS on July 7, 2000, at 11:45:08
In reply to Re: Cam - Zofran?, posted by Cam W. on July 6, 2000, at 14:44:07
> Greg - I believe that Zofran is a selective serotonin-3 (5HT-3) antagonist. 5HT-3 receptors are mainly found in the small intestine (and in the CNS to a lesser degree). By blocking this receptor you decrease the nausea. The 5HT-3 receptor is responsible for the nausea seen as a start-up side effect of the SSRIs. Stimulation of the 5HT-3 receptor by the increased serotonin (as a result of the SSRI) causes nausea, which is resolved when this receptor is desensitized (usually within the first month after starting the SSRI). They use Zofran a lot after chemotherapy.
What is the generic name for Zofran?Where does Zofran exert its antiemetic effects - brain or gut?
Is Zofran devoid or 5-HT2 antagonism?
- Scott
Posted by Greg on July 7, 2000, at 12:18:01
In reply to Re: Cam - Zofran?, posted by SLS on July 7, 2000, at 11:45:08
Scott,
Here is some info I was able to obtain:
Antagonizes 5HT3 receptors, blocks serotonin.
Ondansetron (Zofran) is an antimetic drug, used primarily for the treatment and prevention of severe vomiting. Ondansetron (Zofran) is used after chemotherapy to prevent or treat vomiting. It can be used to prevent or treat vomiting in overdose victims and MAY help treat the symptoms of schizophrenia.
All I know is that it works VERY well for me.
Greg
This is the end of the thread.
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