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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by Brian F on April 13, 2001, at 15:27:35
Is there a difference between Pindolol and Inderal as
far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
The reason I ask is that I am currently without prescription coverage and have found inderal to be more
affordable.
Thank You
Posted by JohnX on April 14, 2001, at 5:10:51
In reply to Inderal-vs-Pindolol, posted by Brian F on April 13, 2001, at 15:27:35
> Is there a difference between Pindolol and Inderal as
> far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
> The reason I ask is that I am currently without prescription coverage and have found inderal to be more
> affordable.
> Thank YouInderal is more potent. The medication fully blocks a receptor that reacts to adrenaline and causes the symptoms you describe. Pindolol is a partial antagonist at that receptor site.
-John
Posted by SLS on April 14, 2001, at 18:39:42
In reply to Re: Inderal-vs-Pindolol, posted by JohnX on April 14, 2001, at 5:10:51
> > Is there a difference between Pindolol and Inderal as
> > far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
> > The reason I ask is that I am currently without prescription coverage and have found inderal to be more
> > affordable.
> > Thank You
>
> Inderal is more potent. The medication fully blocks a receptor that reacts to adrenaline and causes the symptoms you describe. Pindolol is a partial antagonist at that receptor site.
>
> -John
Hi folks.Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
- Scott
Posted by SalArmy4me on April 14, 2001, at 19:49:23
In reply to Inderal-vs-Pindolol, posted by Brian F on April 13, 2001, at 15:27:35
I am on pindolol as my ONLY antidepressant--that's how powerful it is. I'm trying to spread the word about this... people generally have a tough time believing that a blood-pressure medication could help them at all with a mental disease.
> Is there a difference between Pindolol and Inderal as
> far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
> The reason I ask is that I am currently without prescription coverage and have found inderal to be more
> affordable.
> Thank You
Posted by JohnX on April 15, 2001, at 22:21:10
In reply to Re: Inderal-vs-Pindolol, posted by SLS on April 14, 2001, at 18:39:42
> > > Is there a difference between Pindolol and Inderal as
> > > far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
> > > The reason I ask is that I am currently without prescription coverage and have found inderal to be more
> > > affordable.
> > > Thank You
> >
> > Inderal is more potent. The medication fully blocks a receptor that reacts to adrenaline and causes the symptoms you describe. Pindolol is a partial antagonist at that receptor site.
> >
> > -John
>
>
> Hi folks.
>
> Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
>
>
> - ScottScott,
Propranolol from what I have seen also has an antagonist effect on the serotonin 5ht-1a receptor. However, it has not been shown to have much of an anti-depressant benefit. Many markers of anti-depressant action are down-regulation of beta-adrenoreceptor. Propranolol being a full beta blocker actually has a potential side effect of inducing depression as it potently blocks the beta-adrenoreceptor. Pindolol is a partial antagonist (or agonist, which ever way you look at it). So I suspect this is part of the reason that it does not induce depression and the 5ht action is anti-depressant. Any thoughts?
As far as blood pressure medications, my neurologist tells me that pindolol is hardly ever used because it is such a crummy bp med. Most docs I have mentioned it to have never even heard of it (besides the psychiatrist). But they all are familiar with Inderal.
From what I hear, Inderal is the med of choice for things like stage fright, aka any adrenaline related anxiety symptoms.
Here is an example reference to propranolol 5ht-1a antagonism (I have seen others):
Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle.
Pain 2000 Feb;84(2-3):339-46 (ISSN: 0304-3959)
Abstract: We have previously reported that intramuscular injection of serotonin (5-HT) into the masseter muscle elicits pain and allodynia/hyperalgesia in healthy subjects. The aim of this study was to investigate whether the 5-HT(3) receptor antagonist granisetron or 5-HT(1A) receptor antagonist propranolol can reduce 5-HT induced pain and allodynia/hyperalgesia in
the masseter muscle....BTW, the reason I'm aware of this is because I have had chronic bruxism (teeth grinding) and tension headaches and there is evidence that both meds like propranolol and buspar can reduce bruxism. The mode of action of propranolol is thought to be mainly due to its serotonegic workings (as does buspar).
-John
Posted by SalArmy4me on April 15, 2001, at 23:54:19
In reply to Re: Inderal-vs-Pindolol » SLS, posted by JohnX on April 15, 2001, at 22:21:10
Thank you for your thoughtful and complete response to the question.
Posted by SLS on April 16, 2001, at 0:23:54
In reply to Re: Inderal-vs-Pindolol » SLS, posted by JohnX on April 15, 2001, at 22:21:10
> > Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
> Propranolol from what I have seen also has an antagonist effect on the serotonin 5ht-1a receptor. However, it has not been shown to have much of an anti-depressant benefit. Many markers of anti-depressant action are down-regulation of beta-adrenoreceptor. Propranolol being a full beta blocker actually has a potential side effect of inducing depression as it potently blocks the beta-adrenoreceptor. Pindolol is a partial antagonist (or agonist, which ever way you look at it). So I suspect this is part of the reason that it does not induce depression and the 5ht action is anti-depressant. Any thoughts?
Thanks for the correction, John.I was surprised to see propanolol listed as a 5-HT1a antagonist, as I have not seen this mentioned in the literature I have come across. Pindolol seems to be the drug more often chosen as the probe in experiments. When I looked specifically for studies for which propanolol was used, it seemed to be considered as being very close to pindolol in potency.
You are quite a bit more familiar with the relative actions of these drugs on NE beta receptors than am I. A possibly important consideration in comparing the antidepressant effects of pindolol versus propanolol is that pindolol seems to show a higher affinity as an antagonist of presynaptic 5-HT1b autoreceptors. This action would act synergistically with its 5-HT1a antagonism to promote an increase in serotonergic neurotransmission. Perhaps, as you have stated, pindolol is only a partial antagonist at NE beta receptors, it might be less depressogenic than propanolol (I believe that notion that propanolol is depressogenic is still a point of debate). Thus, it is conceivable that the antidepressant effects of pindolol mediated through 5-HT1a/b antagonism predominate over a reduced depressogenic potential. Conversely, the relative lack of 5-HT1b antagonism by propanolol, coupled with its more potent NE beta antagonism, yields a net neutral or depressogenic result.
Thanks for motivating me to look into it. The thoughts I offered here seem too simplistic to me, and something seems to be missing. I’ll let you fill in the blanks.
:-)
- Scott
Posted by JohnX on April 16, 2001, at 3:05:17
In reply to Re: Inderal-vs-Pindolol » JohnX, posted by SLS on April 16, 2001, at 0:23:54
>
> > > Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
>
>
> > Propranolol from what I have seen also has an antagonist effect on the serotonin 5ht-1a receptor. However, it has not been shown to have much of an anti-depressant benefit. Many markers of anti-depressant action are down-regulation of beta-adrenoreceptor. Propranolol being a full beta blocker actually has a potential side effect of inducing depression as it potently blocks the beta-adrenoreceptor. Pindolol is a partial antagonist (or agonist, which ever way you look at it). So I suspect this is part of the reason that it does not induce depression and the 5ht action is anti-depressant. Any thoughts?
>
>
> Thanks for the correction, John.
>
> I was surprised to see propanolol listed as a 5-HT1a antagonist, as I have not seen this mentioned in the literature I have come across. Pindolol seems to be the drug more often chosen as the probe in experiments. When I looked specifically for studies for which propanolol was used, it seemed to be considered as being very close to pindolol in potency.
>
> You are quite a bit more familiar with the relative actions of these drugs on NE beta receptors than am I. A possibly important consideration in comparing the antidepressant effects of pindolol versus propanolol is that pindolol seems to show a higher affinity as an antagonist of presynaptic 5-HT1b autoreceptors. This action would act synergistically with its 5-HT1a antagonism to promote an increase in serotonergic neurotransmission. Perhaps, as you have stated, pindolol is only a partial antagonist at NE beta receptors, it might be less depressogenic than propanolol (I believe that notion that propanolol is depressogenic is still a point of debate). Thus, it is conceivable that the antidepressant effects of pindolol mediated through 5-HT1a/b antagonism predominate over a reduced depressogenic potential. Conversely, the relative lack of 5-HT1b antagonism by propanolol, coupled with its more potent NE beta antagonism, yields a net neutral or depressogenic result.
>
> Thanks for motivating me to look into it. The thoughts I offered here seem too simplistic to me, and something seems to be missing. I’ll let you fill in the blanks.
>
> :-)
>
>
> - ScottHi Scott,
I'm not an expert on these beta-blockers by any means, I just know what I experienced on Inderal and information given to me by a Neurologist. This spurred me to try to better understand the actions of Inderal. Seems it is better used as an anti-anxiety agent. It has been studied for the use of bruxism as well as other ailments like tension headaches. It worked for me but the neurologist took me off of it because he was afraid it could exacerbate my depression (it is listed as a potential side effect).
In a chapter on treatment for neuroleptic induced EPS in the American Psychiatric Press textbook of Psychopharmacology, beta-blockers like Inderal were listed as being very effective in treating symptoms such as akathasia . Thus they are sometimes helpful in the use of RLS.
I'm not an expert on the mode of action, but I think it may have more to do with the 5ht-1a action somehow inhibiting serotonergic firing of the raphe extensions than anything the beta-blockade does (You probably know more than me about the specifics of 5ht-1 modulation). The raphe extensions modulate dopamine firing into the prefrontal cortex (where the neuronal control of masticatory muscles are). A hypodopaminergic prefrontal cortex can cause facial muscular contractions. Hypodopaminergic states can also cause akathasia (feelings of restlessness as in RLS). My experience is that beta-blockers,dopaminergic meds,and 5ht-2 antagonists releave my tension headaches. 5ht-2 antagonism will also relieve hypodopaminergic prefrontal cortex state. I believe that my treatment by SSRI's may have induced my chronic problems since they triggered them very badly when I took them.
My reactions to anti-depressants was quite bizarre. When I took ADs that worked like Zoloft, they usually induced a short lived manic state followed by a sporadic switch into a completely emotionless state with massive muscle contraction in my face. I found an article about SSRI induced tension headaches (specifically pointed the finger at Zoloft) and it talked about the raphe serotonergic modulation of mesocortical dopamine firing and suggested treating the headaches with buspar (or a 5ht-2 antagonist).
I would almost call my reaction to the ADs as a "schizophrenic" like switch from positive to negative psychosis. Negative psychosis is characterized by emotional numbing and is believed from my research to be related to hypodopamergic (pre)frontal cortex. That's why 5ht-2 antagonism in the atypical anti-psychotics better relieve the negative aspects of schizophrenia. I also believe that the 5ht-2 antagonism in meds like zyprexa relieve anhedonia,dysthymia and other sometimes difficult to treat depression symptoms. Just my hypothesis....
any follow up thoughts?
-John
Posted by Cecilia on April 17, 2001, at 0:44:44
In reply to Inderal-vs-Pindolol, posted by Brian F on April 13, 2001, at 15:27:35
What is the difference between Atenolol and Pindolol? I`ve taken Atenolol for the past 12 years for hypertension; it probably helps a little with anxiety too. I asked my pdoc once whether perhaps I should switch to Pindolol to augment whatever AD I was trying at the time, he said he doubted it would do anything different than the Atenolol and in any case the research only showed that Pindolol speeded up the response to AD`s not made them work if they didn`t.
Posted by KarenRB53 on April 15, 2008, at 12:43:58
In reply to Re: Inderal-vs-Pindolol » SLS, posted by JohnX on April 16, 2001, at 3:05:17
> >
> > > > Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
> >
> >
> > > Propranolol from what I have seen also has an antagonist effect on the serotonin 5ht-1a receptor. However, it has not been shown to have much of an anti-depressant benefit. Many markers of anti-depressant action are down-regulation of beta-adrenoreceptor. Propranolol being a full beta blocker actually has a potential side effect of inducing depression as it potently blocks the beta-adrenoreceptor. Pindolol is a partial antagonist (or agonist, which ever way you look at it). So I suspect this is part of the reason that it does not induce depression and the 5ht action is anti-depressant. Any thoughts?
> >
> >
> > Thanks for the correction, John.
> >
> > I was surprised to see propanolol listed as a 5-HT1a antagonist, as I have not seen this mentioned in the literature I have come across. Pindolol seems to be the drug more often chosen as the probe in experiments. When I looked specifically for studies for which propanolol was used, it seemed to be considered as being very close to pindolol in potency.
> >
> > You are quite a bit more familiar with the relative actions of these drugs on NE beta receptors than am I. A possibly important consideration in comparing the antidepressant effects of pindolol versus propanolol is that pindolol seems to show a higher affinity as an antagonist of presynaptic 5-HT1b autoreceptors. This action would act synergistically with its 5-HT1a antagonism to promote an increase in serotonergic neurotransmission. Perhaps, as you have stated, pindolol is only a partial antagonist at NE beta receptors, it might be less depressogenic than propanolol (I believe that notion that propanolol is depressogenic is still a point of debate). Thus, it is conceivable that the antidepressant effects of pindolol mediated through 5-HT1a/b antagonism predominate over a reduced depressogenic potential. Conversely, the relative lack of 5-HT1b antagonism by propanolol, coupled with its more potent NE beta antagonism, yields a net neutral or depressogenic result.
> >
> > Thanks for motivating me to look into it. The thoughts I offered here seem too simplistic to me, and something seems to be missing. Ill let you fill in the blanks.
> >
> > :-)
> >
> >
> > - Scott
>
> Hi Scott,
>
> I'm not an expert on these beta-blockers by any means, I just know what I experienced on Inderal and information given to me by a Neurologist. This spurred me to try to better understand the actions of Inderal. Seems it is better used as an anti-anxiety agent. It has been studied for the use of bruxism as well as other ailments like tension headaches. It worked for me but the neurologist took me off of it because he was afraid it could exacerbate my depression (it is listed as a potential side effect).
>
> In a chapter on treatment for neuroleptic induced EPS in the American Psychiatric Press textbook of Psychopharmacology, beta-blockers like Inderal were listed as being very effective in treating symptoms such as akathasia . Thus they are sometimes helpful in the use of RLS.
>
> I'm not an expert on the mode of action, but I think it may have more to do with the 5ht-1a action somehow inhibiting serotonergic firing of the raphe extensions than anything the beta-blockade does (You probably know more than me about the specifics of 5ht-1 modulation). The raphe extensions modulate dopamine firing into the prefrontal cortex (where the neuronal control of masticatory muscles are). A hypodopaminergic prefrontal cortex can cause facial muscular contractions. Hypodopaminergic states can also cause akathasia (feelings of restlessness as in RLS). My experience is that beta-blockers,dopaminergic meds,and 5ht-2 antagonists releave my tension headaches. 5ht-2 antagonism will also relieve hypodopaminergic prefrontal cortex state. I believe that my treatment by SSRI's may have induced my chronic problems since they triggered them very badly when I took them.
>
> My reactions to anti-depressants was quite bizarre. When I took ADs that worked like Zoloft, they usually induced a short lived manic state followed by a sporadic switch into a completely emotionless state with massive muscle contraction in my face. I found an article about SSRI induced tension headaches (specifically pointed the finger at Zoloft) and it talked about the raphe serotonergic modulation of mesocortical dopamine firing and suggested treating the headaches with buspar (or a 5ht-2 antagonist).
>
> I would almost call my reaction to the ADs as a "schizophrenic" like switch from positive to negative psychosis. Negative psychosis is characterized by emotional numbing and is believed from my research to be related to hypodopamergic (pre)frontal cortex. That's why 5ht-2 antagonism in the atypical anti-psychotics better relieve the negative aspects of schizophrenia. I also believe that the 5ht-2 antagonism in meds like zyprexa relieve anhedonia,dysthymia and other sometimes difficult to treat depression symptoms. Just my hypothesis....
>
> any follow up thoughts?
>
> -John
>
>
>
This is such an old posting I don't know if you'll get it or not. My question is ...Prozac works best for my depression however because I have essential tremor it does cause the tremor to worsen at times and also the Prozac does nothing to help my anxiety. In your opinion, would you think I should try Propranolol or Pindolol? Thanks for any advice.Karen
Posted by undopaminergic on April 16, 2008, at 9:47:04
In reply to Re: Inderal-vs-Pindolol, posted by KarenRB53 on April 15, 2008, at 12:43:58
> >
> This is such an old posting I don't know if you'll get it or not. My question is ...Prozac works best for my depression however because I have essential tremor it does cause the tremor to worsen at times and also the Prozac does nothing to help my anxiety. In your opinion, would you think I should try Propranolol or Pindolol? Thanks for any advice.
>
> Karen
>Beta-blockers (eg. propranolol & pindolol) are one of the most common treatments for essential tremor. On the other hand, I'm inclined to think that antiparkinsonian agents and stimulants would be more effective against the tremor induced by SSRIs (eg. Prozac), which is of a hypodopaminergic nature.
Posted by SLS on April 16, 2008, at 9:52:58
In reply to Re: Inderal-vs-Pindolol, posted by undopaminergic on April 16, 2008, at 9:47:04
I think the most important and unique of the properties of pindolol is its ability to block 5-HT1a somato-dentric autoreceptors. My guess is that any antidepressant activity of this drug is due to this mechanism.
- Scott
Posted by Shadowplayers721 on April 17, 2008, at 0:44:33
In reply to Re: Inderal-vs-Pindolol, posted by KarenRB53 on April 15, 2008, at 12:43:58
I am trying Inderal with Lexapro. I couldn't take it with Lexapro and Cymbalta. I was feeling suicidal. It was awful. I got off of the Cymbalta and I felt much better. I think the Inderal is improving the Tremor some, but I am on a low dose currently. I am slowing trying to increase it.
Posted by KarenRB53 on April 17, 2008, at 8:12:35
In reply to Re: Inderal-vs-Pindolol, posted by Shadowplayers721 on April 17, 2008, at 0:44:33
> I am trying Inderal with Lexapro. I couldn't take it with Lexapro and Cymbalta. I was feeling suicidal. It was awful. I got off of the Cymbalta and I felt much better. I think the Inderal is improving the Tremor some, but I am on a low dose currently. I am slowing trying to increase it.
Is your tremor due to the medications or do you have essential tremor? Also, did you doctor say the inderal would help with anxiety or is it strictly for the tremor?
Karen
Posted by KarenRB53 on April 17, 2008, at 8:21:05
In reply to Re: Inderal-vs-Pindolol, posted by SLS on April 16, 2008, at 9:52:58
> I think the most important and unique of the properties of pindolol is its ability to block 5-HT1a somato-dentric autoreceptors. My guess is that any antidepressant activity of this drug is due to this mechanism.
>
>
> - Scott
I have read that Inderal (propranolol)can actually cause depression whereas the pindolol will not????Karen
Posted by Shadowplayers721 on April 17, 2008, at 9:51:18
In reply to Re: Inderal-vs-Pindolol, posted by KarenRB53 on April 17, 2008, at 8:21:05
The doctor is calling it Essential tremor +, because it's atypical of Essential tremor and it's not Parkinson's. No, it wasn't caused by my medications. I had it prior to taking medications. I have problems with vision too.
Oh, yes, Inderal does cause depression. My doctor increased the Lexapro and took me off the Cymbalta . That has helped the depression. The depression overcame me so rapidly that I almost didn't make the connection. I realized it was the triangle to the drugs. Like I said, I was on the verge of suicide & it would have been totally drug related.
I haven't heard of Pindolol before. Have you tried it for ET? If so, are you finding it effective?
Posted by undopaminergic on April 17, 2008, at 21:49:02
In reply to Re: Inderal-vs-Pindolol, posted by Shadowplayers721 on April 17, 2008, at 9:51:18
Propranolol is very lipid soluble and crosses the blood-brain-barrier easily. Furthermore, it blocks beta2-adrenergic receptors in addition to the beta1-adrenoceptors relevant to hypertension.
Atenolol is much less likely to have depressive or other CNS effects. Unfortunately, it may also be less effective against tremor, but it may well be worth trying before propranolol.
There are many beta-blockers, and all have slightly different properties, especially as far as pharmacokinetics (metabolism, etc.) and other non-cardiovascular effects are concerned, as they were all developed for the purposes of reduction of blood pressure and heart rate.
Posted by KarenRB53 on April 18, 2008, at 10:47:16
In reply to Re: Inderal-vs-Pindolol, posted by Shadowplayers721 on April 17, 2008, at 9:51:18
> The doctor is calling it Essential tremor +, because it's atypical of Essential tremor and it's not Parkinson's. No, it wasn't caused by my medications. I had it prior to taking medications. I have problems with vision too.
>
> Oh, yes, Inderal does cause depression. My doctor increased the Lexapro and took me off the Cymbalta . That has helped the depression. The depression overcame me so rapidly that I almost didn't make the connection. I realized it was the triangle to the drugs. Like I said, I was on the verge of suicide & it would have been totally drug related.
>
> I haven't heard of Pindolol before. Have you tried it for ET? If so, are you finding it effective?
I've not tried the Pindolol but have read that it does not cause depression like propranolol (Inderal) does because it does not cross the blood brain barrier, however, from what I read it does not help as much with the tremor. I have enough depression without adding to it so I'm concerned with using the Inderal. I'm wondering if its dose related as far as depression goes. If I only took 10mg daily would it effect the depression the same as a higher dose? Also, does anyone know if its safe to use Ativan if you're taking Inderal daily?
Posted by Shadowplayers721 on April 18, 2008, at 20:02:32
In reply to Re: Inderal-vs-Pindolol, posted by KarenRB53 on April 18, 2008, at 10:47:16
My tremors are serious enough that I have to take something for them. So, the neurologist did put me on the Inderal. I have noticed an improvement. The pdoc increased the lexapro from 10 mg to 20 and dropped the Cymbalta. I also take Topamax daily too. I take Klonopin on as needed basis. I find that I am super tired with the combo of Inderal and Klonopin. I sleep and sleep.
Sometimes, I just have to take the Klonopin in going out. My tremors are quite handicapping. :(
It seems that a combination of medications are key in helping my tremors lesson.
I am sleepy a lot, but I rather that than anxiety. Anxiety is quite painful.
Posted by undopaminergic on April 18, 2008, at 22:02:53
In reply to Re: Inderal-vs-Pindolol, posted by KarenRB53 on April 18, 2008, at 10:47:16
Pindolol does cross the blood-brain-barrier quite readily, but some of its features may make up for the potentially depressive effect of beta-blockade.
This is the end of the thread.
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