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Dr. Bob is Robert Hsiung, MD,
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Posted by Cam W. on April 16, 2001, at 20:29:50
Dr.Richelson - I noticed that in your slide of alpha-1 adrenergic receptor binding that Effexor had no binding potential. I have seen clinically and have read in some articles and reviews that a small portion of patients (esp. those one doses of more than 300mg qd) do have significant increases in blood pressure. I have noticed that a few of these have been transient (ie disappear within a week), while others have been sustained, requiring a dosage decrease or, more commonly, a switch to another antidepressant.
Could you please comment on a proposed mechanism of action for this blood pressure increase. Could the lack of alpha-adrenergic antagonism be a clinical difference in what we see in vitro (or in animal models), with what occurs in humans in vivo (ie actual antagonism of alpha-adrenergic receptors in some people in vivo).
Thanks for your time - Cam W.
Posted by willow on April 16, 2001, at 21:10:16
In reply to RICHELSON: Increased bp with Effexor, posted by Cam W. on April 16, 2001, at 20:29:50
Cam
Again like usual I didn't understand much of the scientific talk. My bp had been high and I was having physcial symptoms when active. With a small decrease in caffeine I was able to lower my bp without lowering or changing from the effexor. Caffeine by itself can increase bp, but why do the two together have such an increase?
Willow
Posted by Cam W. on April 16, 2001, at 23:36:22
In reply to Increased bp with Effexor, posted by willow on April 16, 2001, at 21:10:16
Willow - That's what I'm asking Dr.Richelson. I had just assumed (or actually was told at a conference a few years ago) that the blood pressure increase was due to alpha-receptor antagonism. Dr.Richelson's shows otherwise. So, I'm just as curious as you are. - Cam
> Cam
>
> Again like usual I didn't understand much of the scientific talk. My bp had been high and I was having physcial symptoms when active. With a small decrease in caffeine I was able to lower my bp without lowering or changing from the effexor. Caffeine by itself can increase bp, but why do the two together have such an increase?
>
> Willow
This is the end of the thread.
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