Psycho-Babble Medication Thread 64693

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Drug-induced Sexual Dysfunction Augmentation

Posted by SalArmy4me on May 30, 2001, at 1:22:49

Methylphenidate †
- 5-40 mg/d
- For SSRIs or venlafaxine
- Libido, arousal, orgasm

Dextroamphetamine †
- 5-40 mg/d
- Avoid night dosing (insomnia)
- Libido, arousal, orgasm

Pemoline †
- 18.75-75 mg/d
- Check liver function
- Libido, arousal, orgasm

Ginkgo biloba extract †
- 180-240 mg/d, tid, divided doses
- Potential increased clotting time, possible flatulence
- Libido, arousal, orgasm

Bethanechol †
- 10-50 mg prn 1 hour before sex
- Used for anticholinergic side effects (TCAs, paroxetine); produces cholinergic side effects
- Arousal

Neostigmine †
- 200 mg/d, tid divided doses
- Used for anticholinergic side effects (TCAs, paroxetine); produces cholinergic side effects
- Arousal

Estrogen creams or lubricants
- As needed
- For vaginal dryness, atrophy of vaginal tissue
- Arousal

Amantadine
- 100 mg bid
- Caution in patients predisposed to psychosis
- Orgasm

Cyproheptadine
- 4-12 mg qhs
- MAOIs, TCAs, SSRIs, venlafaxine; watch for reemergence of depressive symptoms; sedating
- Orgasm

Buspirone †
- 30-60 mg/d, bid divided doses
-
- Libido, orgasm

Bupropion †
- 75-150 mg/d, qd or bid divided doses
- For SSRIs or venlafaxine, fluoxetine may raise bupropion levels; usual precautionary measures for bupropion
- Libido, arousal, orgasm

Mirtazapine †
- 15-45 mg/d
- For SSRIs, venlafaxine
- Orgasm

Nefazodone †
- Start 50 mg/d, up to 150 mg/d
- SSRIs, venlafaxine
- Orgasm

Granisetron †
- 1 mg prn
- ? Use of other 5-HT3 antagonists
- Orgasm

Sildenafil
- 50-100 mg/d
- Contraindicated with nitrates
- Libido, arousal, orgasm

Yohimbine †
- 5.4 mg tid
- Can be anxiogenic; ? safety with MAOIs
- Libido, arousal, orgasm


 

Re: Drug-induced Sexual Dysfunction Augmentation

Posted by Thrud on May 30, 2001, at 2:00:13

In reply to Drug-induced Sexual Dysfunction Augmentation, posted by SalArmy4me on May 30, 2001, at 1:22:49

Hi Sal.

How does buspirone work? Are there long term side effects which differ from ADs (eg. addiction).
Is it an effective antidepressant?

Thanks.

Thrud

 

Re: Drug-induced Sexual Dysfunction Augmentation » Thrud

Posted by SalArmy4me on May 30, 2001, at 4:27:58

In reply to Re: Drug-induced Sexual Dysfunction Augmentation, posted by Thrud on May 30, 2001, at 2:00:13

From . Landen, Mikael MD et al. Effect of Buspirone on Sexual Dysfunction in Depressed Patients Treated With Selective Serotonin Reuptake Inhibitors. Journal of Clinical Psychopharmacology. 19(3):268-271, June 1999:

"Basically, we're talking about buspirone fighting sexual dysfunction in SSRI's. The mechanism of action in this is not obvious. Selective alpha2 receptor antagonists facilitate sexual behavior in animals; moreover, the alpha2 receptor antagonists yohimbine and mianserin have been reported to reduce SSRI-induced sexual dysfunction in man. Thus, the assumption that the effect of buspirone on sexual function is a result of the alpha2 receptor antagonism exerted by the buspirone metabolite 1-(2-pyrimidyl) piperazine dihydrochloride is not far-fetched. However, given the profound influence of 5-HT1A receptors on sexual activity in rodents, the possibility that the partial agonism exerted by buspirone vis-a-vis this receptor subtype is also of importance in this context and cannot be excluded.

Menkes, D. B.. Buspirone Augmentation of Sertraline. British Journal of Psychiatry. 166(6):823-824, June 1995.
This case-study claims the use of 60-90 mg of buspirone is needed for adequate treatment of depression.

 

Re: Drug-induced Sexual Dysfunction Augmentation » SalArmy4me

Posted by nike on June 2, 2001, at 13:54:33

In reply to Re: Drug-induced Sexual Dysfunction Augmentation » Thrud, posted by SalArmy4me on May 30, 2001, at 4:27:58

> From . Landen, Mikael MD et al. Effect of Buspirone on Sexual Dysfunction in Depressed Patients Treated With Selective Serotonin Reuptake Inhibitors. Journal of Clinical Psychopharmacology. 19(3):268-271, June 1999:
>
> "Basically, we're talking about buspirone fighting sexual dysfunction in SSRI's. The mechanism of action in this is not obvious. Selective alpha2 receptor antagonists facilitate sexual behavior in animals; moreover, the alpha2 receptor antagonists yohimbine and mianserin have been reported to reduce SSRI-induced sexual dysfunction in man. Thus, the assumption that the effect of buspirone on sexual function is a result of the alpha2 receptor antagonism exerted by the buspirone metabolite 1-(2-pyrimidyl) piperazine dihydrochloride is not far-fetched. However, given the profound influence of 5-HT1A receptors on sexual activity in rodents, the possibility that the partial agonism exerted by buspirone vis-a-vis this receptor subtype is also of importance in this context and cannot be excluded.
>
> Menkes, D. B.. Buspirone Augmentation of Sertraline. British Journal of Psychiatry. 166(6):823-824, June 1995.
> This case-study claims the use of 60-90 mg of buspirone is needed for adequate treatment of depression.

>I´ve tried buspirone added to Zoloft to decrease sexual dysfunction. It had no effect at all. What would be the best to try next? Which SSRI causes least(or none!)sexual dysfunction in woman?
/nike

 

Re: Drug-induced Sexual Dysfunction Augmentation » nike

Posted by SalArmy4me on June 2, 2001, at 16:34:10

In reply to Re: Drug-induced Sexual Dysfunction Augmentation » SalArmy4me, posted by nike on June 2, 2001, at 13:54:33

I think they all are bad. But, wellbutrin augmentation is 50% effective: http://www.med.nyu.edu/Psych/aug/

I myself found mirtazapine to increase libido but at the same time, it gave me premature ejaculation.

 

Re: Drug-induced Sexual Dysfunction Augmentation

Posted by Lorraine on June 3, 2001, at 13:09:54

In reply to Re: Drug-induced Sexual Dysfunction Augmentation » nike, posted by SalArmy4me on June 2, 2001, at 16:34:10

Of the SSRIs (although not strictly SSRI's), Wellbutrin and Serzone are the two reported not to have sexual or weight side effects. I took them both--Wellbutrin in the day and Serzone at night. Unfortunately, couldn't tolerate the Wellbutrin.

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