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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by ben on June 30, 2001, at 13:11:05
My doc wants do ad Lamictal to Paxil because my mood is not stable at all. I am always between severe depression and normal. I guess I am not bipolar (after 18 month of illness). Does anyone have good experiences ? I tried Lithium but had terrible nausea. Tried a lot of other AD s. What about the mood stabilizers Tegretol and Depakote ? I am very sensitive to side effects and thats why my doc prefers Lamictal against the others. Tegretol causes dizziness and Depakote weight gain ?
Thanks for your input.
P.S. Tried Zyprexa but a dose of 1.25 mg knocked me out :(
Posted by SalArmy4me on June 30, 2001, at 14:39:57
In reply to Lamictal for unipolar ? Please help, posted by ben on June 30, 2001, at 13:11:05
Lamotrigine works on serotonin, alleviating anxiety and depression (unipolar or bipolar), according to these and other studies:
Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Eur J Pharmacol. 1998 Sep 25;358(1):19-24:
"The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake in vivo. These effects probably reflect an affinity for biogenic amine transporters..."Erfurth A, Amann B, Grunze H. Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?
Neuropsychobiology. 1998 Oct;38(3):200-1:
"The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake..."Kumar TC, Khanna S.
Lamotrigine augmentation of serotonin re-uptake inhibitors in obsessive-compulsive disorder.
Aust N Z J Psychiatry. 2000 Jun;34(3):527-8.Shiah IS, Yatham LN, Lam RW, Zis AP. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
J Affect Disord. 1998 May;49(2):157-62.
Posted by ben on July 1, 2001, at 2:55:03
In reply to Re: Lamictal for unipolar ? Please help, posted by SalArmy4me on June 30, 2001, at 14:39:57
Sounds hopefull but are there babblers on the board with good experinces ?
> Lamotrigine works on serotonin, alleviating anxiety and depression (unipolar or bipolar), according to these and other studies:
>
> Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
> Eur J Pharmacol. 1998 Sep 25;358(1):19-24:
> "The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake in vivo. These effects probably reflect an affinity for biogenic amine transporters..."
>
> Erfurth A, Amann B, Grunze H. Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?
> Neuropsychobiology. 1998 Oct;38(3):200-1:
> "The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake..."
>
> Kumar TC, Khanna S.
> Lamotrigine augmentation of serotonin re-uptake inhibitors in obsessive-compulsive disorder.
> Aust N Z J Psychiatry. 2000 Jun;34(3):527-8.
>
> Shiah IS, Yatham LN, Lam RW, Zis AP. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
> J Affect Disord. 1998 May;49(2):157-62.
This is the end of the thread.
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