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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Jackster on October 6, 2001, at 16:03:02
Hi
I'm currently taking 30mg of Paxil (which I'm fine with - have taken before but it pooped out). My PDoc has added Clomipramine to the mix (for reuptake of the other transmitter - starting with n that I can never remember the name of). I gradually went from 10mg to 20mg and after about 3 weeks I started getting really irritable. I was blowing up at the smallest things and feeling really aggresive. I realise this could definitely by a side effect of the clomirpamine - has anyone else had this effect - and does it eventually go away? (BTW am also taking 2mg of Xanax per day)
Thanks
Jackie
Posted by Mitch on October 7, 2001, at 15:51:35
In reply to A walking fuse of dynamite...., posted by Jackster on October 6, 2001, at 16:03:02
> Hi
>
> I'm currently taking 30mg of Paxil (which I'm fine with - have taken before but it pooped out). My PDoc has added Clomipramine to the mix (for reuptake of the other transmitter - starting with n that I can never remember the name of). I gradually went from 10mg to 20mg and after about 3 weeks I started getting really irritable. I was blowing up at the smallest things and feeling really aggresive. I realise this could definitely by a side effect of the clomirpamine - has anyone else had this effect - and does it eventually go away? (BTW am also taking 2mg of Xanax per day)
>
> Thanks
> Jackie
I would tell your doctor about it before something bad happens. I narrowly escaped losing my job due to temper episodes occuring due to meds. I doubt if you can translate much of my experience with meds and hostility, but there were three meds I had to stop due to really bad hostility: Buspar, Effexor, and now Remeron. All three of them effect norepinephrine (there's the N word you were looking for). Specifically, the Remeron and the Buspar are alpha2 antagonists which enhance norepinephrine. All I know is that I more than a few times felt like punching my boss square in the jaw on several occasions and got stopped from doing so in one instance by a coworker. Also, you mentioned Xanax. Well that can lower your inhibition (like alcohol). So, possibly you get norepi levels up and throw in a little disinhibition from a benzo and you might get some hostility. I also got quite hostile occassionally when I was taking Valium. I am taking Klonopin now and I don't notice that.
good luck,
Mitch
Posted by jay on October 7, 2001, at 22:32:12
In reply to A walking fuse of dynamite...., posted by Jackster on October 6, 2001, at 16:03:02
Hi:
I am no expert, but since Paxil and Clomipramine both affect the reuptake of serotonin, it may be possible you are suffering side-effects of too much serotonin, or maybe something like the "Serotonin Syndrome". Anyhow, you should get to your doc, a walk-in clinic, or even emergency room asap, as you shouldn't be walking around with those feelings. In other words...get help right away!
Best wishes..
Jay
> Hi
>
> I'm currently taking 30mg of Paxil (which I'm fine with - have taken before but it pooped out). My PDoc has added Clomipramine to the mix (for reuptake of the other transmitter - starting with n that I can never remember the name of). I gradually went from 10mg to 20mg and after about 3 weeks I started getting really irritable. I was blowing up at the smallest things and feeling really aggresive. I realise this could definitely by a side effect of the clomirpamine - has anyone else had this effect - and does it eventually go away? (BTW am also taking 2mg of Xanax per day)
>
> Thanks
> Jackie
Posted by Jackster on October 11, 2001, at 1:31:28
In reply to Re: A walking fuse of dynamite.... » Jackster, posted by Mitch on October 7, 2001, at 15:51:35
Thanks for your advice. I talked to my PDoc and he seemed to think that I had 'accelerated moods' from the Paxil. I never had problems before on it, and I didn't have mood swings, just aggression. I feel better after taking my clomipramine dose back down to 10mg which to me indicates that it is the culprit. My PDoc wants me to stay on it until I get used to it. In the meantime I am hopefully going to slowly come of the Xanax.
>
> I would tell your doctor about it before something bad happens. I narrowly escaped losing my job due to temper episodes occuring due to meds. I doubt if you can translate much of my experience with meds and hostility, but there were three meds I had to stop due to really bad hostility: Buspar, Effexor, and now Remeron. All three of them effect norepinephrine (there's the N word you were looking for). Specifically, the Remeron and the Buspar are alpha2 antagonists which enhance norepinephrine. All I know is that I more than a few times felt like punching my boss square in the jaw on several occasions and got stopped from doing so in one instance by a coworker. Also, you mentioned Xanax. Well that can lower your inhibition (like alcohol). So, possibly you get norepi levels up and throw in a little disinhibition from a benzo and you might get some hostility. I also got quite hostile occassionally when I was taking Valium. I am taking Klonopin now and I don't notice that.
> good luck,
> Mitch
This is the end of the thread.
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