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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by SLS on October 7, 2001, at 10:17:27
Any comments?
Thanks.
(still looking for the bullet with my name on it)
- Scott
Posted by Cam W. on October 7, 2001, at 12:34:26
In reply to Sibutramine (Meridia) for depression., posted by SLS on October 7, 2001, at 10:17:27
Scott - Okay, what is it with that stuff? It's "proposed" mechanism of action is serotonin and norepinephrine reuptake inhibitor, with a metabolite blocking dopamine reuptake 3 times less potently than the parent compound blocks the other two reuptake sites.
So, this makes it Effexor™ (venlafaxine)! Where the heck does the weight loss come from? I haven't checked out the relative binding potentials between Meridia™ (sibutramine) and Effexor, but this really baffles me. People still gain weight on Effexor (although not as much as with the SSRIs, esp. Paxil™ - paroxetine). What are they not telling us?
Things that make you go hmmmm! - Cam
Posted by JohnX on October 8, 2001, at 14:03:01
In reply to Sibutramine (Meridia) for depression., posted by SLS on October 7, 2001, at 10:17:27
> Any comments?
>
> Thanks.
>
> (still looking for the bullet with my name on it)
>
> - Scott
This is not effexor (I'm getting this information
from the Merck Index, a dictionary of chemicals
and pharmaceuticals), but I *think* it may
be marketed by the same pharmaceutical manufacturer
Sibutramine is covered under us patent 4,929,629 and
effexor (venlafaxine) 4,535,186. The patent disclosures may
contain more information on the modes of action.
www.uspto.gov.An acquaintance of mine is a pharmacist, and
I remember him complaining about a patient
who came in screaming that when he looked
at the side-effect profile of meridia and
it said potential for weight gain.;).Imho, the best non addictive med for weight
loss is probably Wellbutrin orTopomax,
not Sibutramine.
Of course a stimulant like Adderall works
even better (I shed about 3 lbs per week).
Maybe if there was a medication that could
prevent amphetamine tolerance and was
neuroprotective physicians would be more happy
to prescribe the stimulant for severe obesity
or weight gain side-effects from other meds.
HMMMM.-John
Posted by Elizabeth on October 9, 2001, at 13:03:59
In reply to Re: Sibutramine (Meridia) for depression. » SLS, posted by Cam W. on October 7, 2001, at 12:34:26
> I haven't checked out the relative binding potentials between Meridia™ (sibutramine) and Effexor, but this really baffles me. People still gain weight on Effexor (although not as much as with the SSRIs, esp. Paxil™ - paroxetine). What are they not telling us?
That sibutramine is Just Another Antidepressant. In early preclinical studies, it's often referred to as an antidepressant.
I'd be interested in those binding potentials, if you do happen to look them up.
-elizabeth
P.S. I agree that Paxil seems to be a worse offender than the other SSRIs with regard to weight gain. Wonder why that would be.
Posted by Psychopharm Nut on October 9, 2001, at 16:01:13
In reply to Re: Sibutramine for depression » Cam W., posted by Elizabeth on October 9, 2001, at 13:03:59
Is it addictive?
Posted by Elizabeth on October 10, 2001, at 13:34:58
In reply to Why is Sibutramine a Controlled Substance?, posted by Psychopharm Nut on October 9, 2001, at 16:01:13
Most likely, it was placed in Schedule IV because some rodents chose to self-administer it. It's chemically and pharmacologically similar to venlafaxine.
-elizabeth
Posted by SLS on October 10, 2001, at 14:13:21
In reply to Re: Why is Sibutramine a Controlled Substance? » Psychopharm Nut, posted by Elizabeth on October 10, 2001, at 13:34:58
> Most likely, it was placed in Schedule IV because some rodents chose to self-administer it. It's chemically and pharmacologically similar to venlafaxine.
>
> -elizabeth
Hi Elizabeth.I resent being called a rodent. And it's none of your business how often I self-administer. My acne isn't that bad.
What do you think of sibutramine as an antidepressant?
Do you know of anyone who has ever used it?
Thanks.
- Scott
Posted by Elizabeth on October 11, 2001, at 11:20:07
In reply to Re: Why is Sibutramine a Controlled Substance? » Elizabeth, posted by SLS on October 10, 2001, at 14:13:21
> Hi Elizabeth.
Hi Scott.
> I resent being called a rodent. And it's none of your business how often I self-administer. My acne isn't that bad.
< giggle >
> What do you think of sibutramine as an antidepressant?
Good alternative to Effexor, might have fewer side effects.
> Do you know of anyone who has ever used it?
Yes (with some success).
-elizabeth
Posted by Cam W. on October 11, 2001, at 15:54:34
In reply to Re: Why is Sibutramine a Controlled Substance? » Psychopharm Nut, posted by Elizabeth on October 10, 2001, at 13:34:58
Hmmm... Here in Canada, it is just a regular prescription. - Cam
Posted by Mitch on October 11, 2001, at 23:11:14
In reply to Re: Why is Sibutramine a Controlled Substance? » Elizabeth, posted by Cam W. on October 11, 2001, at 15:54:34
> Hmmm... Here in Canada, it is just a regular prescription. - Cam
Cam,
I have followed this thread over the past few days (and have been curious about the drug), and I wonder if maybe *somehow* the manufacturer *wanted* to get the drug considered a controlled substance to boost sales ("if it is a controlled substance it must be really good-like diet pills from the 60's")???
Mitch
Posted by Elizabeth on October 12, 2001, at 9:59:58
In reply to Re: Why is Sibutramine a Controlled Substance? » Cam W., posted by Mitch on October 11, 2001, at 23:11:14
> ...I wonder if maybe *somehow* the manufacturer *wanted* to get the drug considered a controlled substance to boost sales ("if it is a controlled substance it must be really good-like diet pills from the 60's")???
That's intriguing, and it hadn't occurred to me. That might well have something to do with it.
-elizabeth
This is the end of the thread.
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