![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by loolot on October 7, 2003, at 19:19:38
I am still trying to find a new depression drug
I am on 450 wellbutrin which is pooping out. I am also on cytomel which is giving me some energy but not helping my mood so much.
I tried effexor, ssris and recently adderall, which gave me terrible skin problems
Anyway, I am wondering about topamax now bc I have heard it can be good for atypical depression. How does it work? Is it dopaminergic?
Posted by Shawn. T. on October 7, 2003, at 23:26:46
In reply to topamax-how does it work, posted by loolot on October 7, 2003, at 19:19:38
Topamax (topiramate) is an inhibitor of carbonic anhydrase (CA) isoenzymes; the drug is a more potent inhibitor of CA II and CA IV than of CA I, CA III, and CA VI. This action is responsible for topiramate's effects on GABA-A receptors such as the reduction of depolarizing responses mediated by the receptors (see the second reference for more details). Topiramate has also been shown to inhibit both the fast and persistent components of sodium currents in neocortical cells. In addition, the drug may inhibit L-type voltage-gated calcium channels. Finally, topiramate may inhibit inward currents evoked by some subtypes of kainate and AMPA glutamate receptors.
I'm not aware of any published articles that show that topiramate possesses dopaminergic actions.
http://jpet.aspetjournals.org/cgi/content/full/288/3/960
Shawn
Posted by Sabina on October 7, 2003, at 23:33:02
In reply to Re: topamax-how does it work, posted by Shawn. T. on October 7, 2003, at 23:26:46
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.