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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by 4WD on May 15, 2005, at 16:35:01
Ed - Maybe you can answer this for me, please. Should Inderal begin to work as soon as you take it. Or do you have to wait days or weeks for it to build up in your system before it becomes effective?
Thanks
Marsha
Posted by ed_uk on May 15, 2005, at 17:34:54
In reply to Ed - beta blockers work immediately or not?, posted by 4WD on May 15, 2005, at 16:35:01
Hi,
Inderal should work rapidly- shortly after taking the first dose. Perhaps you should try a higher dose if it's not helping. Personally, Inderal does not help my anxiety, whatever dose I take! For some people, Inderal can relieve palpitations and tremor, it's not usually very effective for other symptoms of anxiety.
Kind regards,
Ed.
Posted by Phillipa on May 15, 2005, at 22:05:54
In reply to Re: Ed - beta blockers work immediately or not? » 4WD, posted by ed_uk on May 15, 2005, at 17:34:54
It also can keep your pulse from going up when you excercise which is dangerous. Although I didn't take inderal, I was given lopressor 25mg and when I used the treadmill I couldn't get my heat rate up. Fondly, Phillipa
Posted by 4WD on May 15, 2005, at 22:37:10
In reply to Re: Ed - beta blockers work immediately or not? » 4WD, posted by ed_uk on May 15, 2005, at 17:34:54
> Hi,
>
> Inderal should work rapidly- shortly after taking the first dose. Perhaps you should try a higher dose if it's not helping. Personally, Inderal does not help my anxiety, whatever dose I take! For some people, Inderal can relieve palpitations and tremor, it's not usually very effective for other symptoms of anxiety.
>
> Kind regards,
> Ed.Thanks, Ed. I didn't feel like it was working at all. I told that to my pdoc and he said I hadn't been taking it long enough. I didnt' think that could be right since people take it before giving a speech, etc. Guess he just wanted me out of his office.
Thanks,
Marsha
Posted by 4WD on May 15, 2005, at 22:39:28
In reply to Re: Ed - beta blockers work immediately or not?, posted by Phillipa on May 15, 2005, at 22:05:54
> It also can keep your pulse from going up when you excercise which is dangerous. Although I didn't take inderal, I was given lopressor 25mg and when I used the treadmill I couldn't get my heat rate up. Fondly, Phillipa
Hi Phillipa,That's really weird. I have trouble getting my heart rate up high enough when I exercise normally. After going on the beta blocker, I found that if I took it in the morning and exercised that afternoon, my heart rate went way up. Maybe because the blocker was wearing off and all the unused adrenaline was just hanging around waiting for a receptor to cling on to!
Marsha
Posted by Phillipa on May 15, 2005, at 22:43:57
In reply to Re: Ed - beta blockers work immediately or not? » Phillipa, posted by 4WD on May 15, 2005, at 22:39:28
Maybe if you were taking inderal that's why. It's short acting and lopressor is good for the day. Maybe what you experienced was similar to what happens with rebound anxiety. That's just a guess. Fondly, Phillipa
Posted by sdb on May 16, 2005, at 11:45:46
In reply to Re: Ed - beta blockers work immediately or not? » 4WD, posted by Phillipa on May 15, 2005, at 22:43:57
I propose oxprenolol (beta1/2-antagonist, MSA and weak ISA) if available. It has definately equal strong blockade response of catecholamines (I have tested it myself by treadmill and by catecholamines). It does not sedate you like inderal, overall less sideeffects. You can think clearer thus you will have better performance. It works very fast (1-2h) if you do not take the long version (slow oxprenolol). According to a monkey study it even increases sexual ability compared to bad sexual sideeffects of Inderal.
Note: Betablockers reduce only physical anxiety symptoms.
There are many abstracts of oxprenolol related performance anxiety:
Curr Med Res Opin. 1976;4(3):241-3. Related Articles, Links
Oxprenolol in the treatment of examination stress.Krishnan G.
In a double-blind preliminary study in 32 students exhibiting symptoms of examination stress, treatment with 80 mg oxprenolol daily or 4 mg diazepam daily were found to be equally effective in relieving anxiety and tension, as assessed by both students and physician. Although students on diazepam became significantly more confident of success than those on oxprenolol, their results were worse than expected. In contrast, students on oxprenolol did not gain in confidence and they were significantly more successful than anticipated by their tutors.
Publication Types:
Clinical Trial
Randomized Controlled TrialPMID: 780063 [PubMed - indexed for MEDLINE]
Posted by Bill LL on May 16, 2005, at 14:21:44
In reply to Re: Ed - beta blockers work immediately or not?, posted by Phillipa on May 15, 2005, at 22:05:54
Have you heard anything specific about the danger? My cardiologist told me about 3 weeks a go that the pulse during exercise effect is not dangerous, but I am very interested in anything that you hve heard. Thanks.
> It also can keep your pulse from going up when you excercise which is dangerous. Although I didn't take inderal, I was given lopressor 25mg and when I used the treadmill I couldn't get my heat rate up. Fondly, Phillipa
Posted by sdb on May 16, 2005, at 14:49:01
In reply to Re: Ed - beta blockers work immediately or not?, posted by Bill LL on May 16, 2005, at 14:21:44
Normally this is absolutely not dangerous if you have normal cardiovascular conditions. It can even prevent heart failure. But it will definately impair your exercise performance.
But if you know that you have a heart/cardiovascular problem ask your cardiologist again or ask another cardiologist to be sure.
Posted by Phillipa on May 16, 2005, at 16:03:24
In reply to Re: Ed - beta blockers work immediately or not?, posted by sdb on May 16, 2005, at 14:49:01
Sorry I can't remember where I read it, but you'e right you won't get the cardiovascular benefits. I am very curious now also. Could they have changed their minds? You know that happens all the time. I think I will google beta blockers and excercise and see what I get. If you come up with anything concrete please post it okay? Fondly, Phillipa
Posted by Phillipa on May 16, 2005, at 16:29:05
In reply to Re: Ed - beta blockers work immediately or not?, posted by sdb on May 16, 2005, at 14:49:01
Well you learn something new everyday. I just did a web search and found two interesting things about beta blockers. One was the common side=effects which include mild chronic fatigue, low excercise tolerance, sedation, nightmares, increased airway resistance, and bradycardia. Okay I knew this but it doesn't say a thing about it being okay or dangerous to excerise. Then I went to another site by a cardiologist which said "Beta blockers say good-bye to excess adrenaline, I'm here first." The excess adrenaline is excreted in the urine. He does say check with your MD first. I think these were all meant for people with known cardiac disease. So, if your doc says okay, than I guess it is. Anyone else? Fondly, Phillipa
Posted by sdb on May 16, 2005, at 18:29:54
In reply to Re: Ed - beta blockers work immediately or not?, posted by Phillipa on May 16, 2005, at 16:29:05
Hello!
There are many betablockers on the market some with more and some with minor to no sideeffects. I have taken almost all betablockers available.
Some Medical Doctors and even a cardiologist said all betablockers do the same. I was pretty angry. That's not true. Of course a betablocker blocks adrenaline somehow on beta1/2 receptors. But there are big differences relating to antioxdant properties, AV-conduction, combined alpha1-antagonist properties, Membran stabilizing action, Intrinsic symphatomimtic action, changing of fat metabolism, receptor up- and downregulation, pharmacokinetics, big differences in sideeffects, lipophil or watersoluble and so on.
I normally have slight hypotension. I had never a problem with betablockers and I use them not to cure a cardiovascular problem. That's of course a big difference. I would like to give only recommendations for betablockers in mental disorders. There are betablockers with very minor sideffects. You do not have to be always tired if you take the right one.
In pharmacology books is often written: The efficacy of betablockers is not fully understood.
The key is: preventing heart from big rise of adrenaline ths less oxygen requirement in situations of stress or work, lowering bloodpressure, decreasing intima-media thickness, more blood flow to coronar arterias thus more oxygen and "nutrition" for the septum, the atrias and ventricals.
If you feel pain in the left arm, the right or left chest or you feel always tired go to a cardiologist.
regards
sdb
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