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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by blueberry on April 22, 2006, at 5:53:58
I'm wondering if there exists out there anything, either herbal or pharmaceutical, that acts primarily as a 5ht2a/2c blocker? I'm not sure, but I believe that is the mechanism by which prozac was the only ssri that was ok for me, and why zyprexa was decent. I'm not sure the dopamine blockade of zyprexa was all that important. Remeron blocks those receptors, but its other mechanisms make me feel much worse than before.
It would be nice to try something that just blocks the 5ht2 receptors but does very little of anything else.
Posted by madeline on April 22, 2006, at 6:55:48
In reply to Natural or medicinal 5ht2 antagonist?, posted by blueberry on April 22, 2006, at 5:53:58
I know one is in the pipe as an anti-hypertensive.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2904312&dopt=Abstract
Posted by linkadge on April 22, 2006, at 8:11:38
In reply to Re: Natural or medicinal 5ht2 antagonist?, posted by madeline on April 22, 2006, at 6:55:48
Prozac was a 5-ht2c antagonist, but I don't think it had any 5-ht2a antagonism.
The only things I can think of are:
Amitryptaline,
Zyprexa,
Valdoxan ?
Periactin
Ritanserin.Feverfew (5-ht2a/b)
SJW (5-ht1d,5-ht2c)(5-ht1d blockade might have efficacy in melancholy)http://journals.medicinescomplete.com/journals/fact/current/fact0704a08g01sr03.htm
Linkadge
Posted by SLS on April 22, 2006, at 8:15:58
In reply to Natural or medicinal 5ht2 antagonist?, posted by blueberry on April 22, 2006, at 5:53:58
Nefazodone.
Agomelatine (Valdoxan) is an antagonist at 5-HT2c, but not at 5-HT2a. It might be available in Europe sometime this year.
- Scott
Posted by blueberry on April 22, 2006, at 13:54:01
In reply to Re: Natural or medicinal 5ht2 antagonist?, posted by linkadge on April 22, 2006, at 8:11:38
Funny how the things I've liked the best...prozac, zyprexa, sjw...all had the 5ht2 antagonism. One that I didn't like though was remeron.
Interesting about sjw. Especially considering that is the only, I mean the only, thing I've ever tried that completely wiped out anhedonia, amotivation and melancholy.
I've never looked at the 5ht1d receptor. What is its function?
If I could go back and do it all over again, and maybe I will, I would do 5mg prozac, 600mg sjw, and 2.5mg zyprexa (which would be increased to a blood level of about 7.5mg by the sjw metabolic effects on it.) 10mg prozac + 5mg zyprexa + 600mg sjw was the best I ever felt in my entire life. What an idiot to let it go. I was afraid of such a weird combination and longterm complications or risks.
Anyway, thank you very much for taking your time to respond. As always, you are generously helpful.
> Prozac was a 5-ht2c antagonist, but I don't think it had any 5-ht2a antagonism.
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> The only things I can think of are:
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> Amitryptaline,
> Zyprexa,
> Valdoxan ?
> Periactin
> Ritanserin.
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> Feverfew (5-ht2a/b)
> SJW (5-ht1d,5-ht2c)(5-ht1d blockade might have efficacy in melancholy)
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> http://journals.medicinescomplete.com/journals/fact/current/fact0704a08g01sr03.htm
>
> Linkadge
>
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Posted by Meri-Tuuli on April 22, 2006, at 14:30:52
In reply to Re: Natural or medicinal 5ht2 antagonist? » linkadge, posted by blueberry on April 22, 2006, at 13:54:01
Hi Blueberry!
Have you ever tried SJW on its own?? Or have you never had the opportunity to do so? Did you take kira? Do you notice any difference between the brands? I tried looking into sjw at that Kelly's sjwinfo.org site, but the discussion forum I think difficult to follow and nowhere near as helpful as here!!
Kind regards
Meri
Posted by linkadge on April 22, 2006, at 14:41:59
In reply to Re: Natural or medicinal 5ht2 antagonist? » linkadge, posted by blueberry on April 22, 2006, at 13:54:01
I'm not sure of the exact function of the 5-ht1d receptors. I know they have been implicated in OCD, but I think if they're stimulated too much it can contribute to melancholy.
SSRI's directly agonize 5-ht1d and lead to desensitization. There has been talk of adding 5-ht1d antagonists to SSRI's to improve responce.
http://biopsychiatry.com/5ht1dzol.htm
SJW is a good herb. People underestimate it, but it can be very good for anhedonia. Triple uptake inhibitor plus some interesting receptor action. What more could one ask for. I think synthetic SJW is in the pipelines.
Linkadge
Posted by linkadge on April 22, 2006, at 14:42:39
In reply to Re: Natural or medicinal 5ht2 antagonist? » linkadge, posted by blueberry on April 22, 2006, at 13:54:01
Remeron would probably be better if it didn't have the blood antihistamine effect. It is a very strong antihistamine.
Linkadge
Posted by dondon on April 22, 2006, at 22:23:42
In reply to Natural or medicinal 5ht2 antagonist?, posted by blueberry on April 22, 2006, at 5:53:58
ginkgo biloba
Posted by Dr. Bob on April 24, 2006, at 19:05:06
In reply to Re: Natural or medicinal 5ht2 antagonist? » blueberry, posted by Meri-Tuuli on April 22, 2006, at 14:30:52
> Have you ever tried SJW on its own??
Sorry to interrupt, but I'd like to redirect follow-ups regarding natural 5ht2 antagonists to Psycho-Babble Alternative. Here's a link:
http://www.dr-bob.org/babble/alter/20060313/msgs/636663.html
Thanks,
Bob
This is the end of the thread.
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