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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Minsc22 on July 5, 2010, at 14:40:44
Hello,
i take 450 mg of bupropion for a lack of motivation, anhedonia.
There is an enhancement but i would like a better response.
The problem is when i take an other stimulant medication, my previous state returns with no motivation.
I tried selegiline, reboxetine, modafinil and sulpiride in addition of bupropion.
Each time, i have the opposite reaction what i expect.
Is there an explanation?
Thanks for your help.
Posted by Minsc22 on July 5, 2010, at 14:49:50
Each time, all the medication are in addition of bupropion 450 mg
Posted by Phillipa on July 5, 2010, at 20:01:45
In reply to unusual reaction with activating medication, posted by Minsc22 on July 5, 2010, at 14:40:44
Paradoxical reaction opposite of what med was intended for. Phillipa
Posted by Christ_empowered on July 6, 2010, at 4:32:12
In reply to unusual reaction with activating medication, posted by Minsc22 on July 5, 2010, at 14:40:44
I don't really know what to tell you...sometimes you can be stimulated to the point of inactivity, like the over-medicated "Ritalin Kids" who stared off into space because their ritalin doses were so high. That's all I can think of.
Could you try another approach? Supplements, vitamins? Biofeedback? Self-help? Therapy?
Posted by bleauberry on July 7, 2010, at 17:57:52
In reply to unusual reaction with activating medication, posted by Minsc22 on July 5, 2010, at 14:40:44
Depending on the sensitivity of the dopamine receptors, and a confusing relation to the adrenal/thyroid axis, stimulating meds can have paradoxical reactions.
Case in point, the ADHD kid who takes ritalin and becomes calm. Ritalin would send a normal person into hyper activity.
I think the mysteries of the dopamine system are way beyond our comprehension. You kind of just have to gather clues as to how you respond to this or that, and then use those clues to your advantage going forward in terms of doses and med choices. You kind of have to forget about theory stuff and textbooks and instead go with what your body is trying to tell you.
Wellbutrin made me really tired and really darkly depressed.
Posted by Minsc22 on July 8, 2010, at 6:40:51
In reply to Re: unusual reaction with activating medication, posted by bleauberry on July 7, 2010, at 17:57:52
> Depending on the sensitivity of the dopamine receptors, and a confusing relation to the adrenal/thyroid axis, stimulating meds can have paradoxical reactions.
>
> Case in point, the ADHD kid who takes ritalin and becomes calm. Ritalin would send a normal person into hyper activity.
>
> I think the mysteries of the dopamine system are way beyond our comprehension. You kind of just have to gather clues as to how you respond to this or that, and then use those clues to your advantage going forward in terms of doses and med choices. You kind of have to forget about theory stuff and textbooks and instead go with what your body is trying to tell you.
>
> Wellbutrin made me really tired and really darkly depressed.Thanks for your help.
I tried 4 ssri and snri + the other meds and all were ineffective.
In opposite of your reaction, bupropion is the only one gives me interest in things, a little motivation and i must order on internet because is not available in my country.
Not much alternatives...
I will try maybe a dopamine agonist like mirapex.PS : sorry for bad english
This is the end of the thread.
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