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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by MRM1666 on June 4, 2011, at 8:52:21
I've read that some people have had Desipramine, or Nortriptyline or Ritalin, etc. added to Parnate.
I've spoken with my psychiatrist about this but he's wary of doing so given the possible consequences. Has anyone, in fact, done this sort of thing? And please let me know what your experience was.
My diagnosis is major depression and my primary symptom is tiredeness.
Thank you again.
Posted by Phillipa on June 4, 2011, at 11:32:34
In reply to Parnate boosted by Desipramine, Nortryptaline, etc, posted by MRM1666 on June 4, 2011, at 8:52:21
In all seriousness could you just be tired emotionally and physcially of the battle. Are you sleeping enough? Phillipa
Posted by zonked on June 4, 2011, at 13:50:06
In reply to Parnate boosted by Desipramine, Nortryptaline, etc, posted by MRM1666 on June 4, 2011, at 8:52:21
Sure!
Parnate + dextroamphetamine = potentiated AD effect of Parnate, was able to get away with a lower dose of Parnate this way. ADD symptoms improved. No effects on blood pressure.
Unfortunately, stimulants (for me) follow the law of diminishing returns over time... including Parnate itself.
Parnate + methylphenidate = OMG anxiety through the roof, increased blood pressure quite a bit.
YMMV
-z
> I've read that some people have had Desipramine, or Nortriptyline or Ritalin, etc. added to Parnate.
>
> I've spoken with my psychiatrist about this but he's wary of doing so given the possible consequences. Has anyone, in fact, done this sort of thing? And please let me know what your experience was.
>
> My diagnosis is major depression and my primary symptom is tiredeness.
>
> Thank you again.
Posted by MRM1666 on June 4, 2011, at 16:15:41
In reply to Re: Parnate boosted by Desipramine, Nortryptaline, etc » MRM1666, posted by zonked on June 4, 2011, at 13:50:06
Thank you for your response.
Yes, my psychiatrist told me of the possibility of increased blood pressure, etc. (including death) as a result of being on Parnate and either
Desipramine, Nortryptaline.I'm wondering if anyone can differentiate the experience of being on Parnate and a TCA from the experience of being on Parnate and a stimulant.
> Sure!
>
> Parnate + dextroamphetamine = potentiated AD effect of Parnate, was able to get away with a lower dose of Parnate this way. ADD symptoms improved. No effects on blood pressure.
>
> Unfortunately, stimulants (for me) follow the law of diminishing returns over time... including Parnate itself.
>
> Parnate + methylphenidate = OMG anxiety through the roof, increased blood pressure quite a bit.
>
> YMMV
>
Posted by desolationrower on June 5, 2011, at 16:38:26
In reply to Re: Parnate boosted by Desipramine, Nortryptaline, etc, posted by MRM1666 on June 4, 2011, at 16:15:41
I was not able to convince my pdoc to rx this, or find a new pdoc before the parnate got rid of my depression and i decided i could come off it to focus on treating ADHD.
If slowly titrated, i think the TCA would reduce risk of blood pressure problems (preventing tyramine crisis), though average bp would probably go up. nort would also reduce/prevent risk of 5ht syndrome.
i did use adrafinil with parnate to reduce tiredness.
There have been some clinical trials invovling combination of TCA and MAOI that you might want to show him or her.
-d/r
Posted by jono_in_adelaide on June 5, 2011, at 19:37:07
In reply to Re: Parnate boosted by Desipramine, Nortryptaline, etc, posted by desolationrower on June 5, 2011, at 16:38:26
Dr Ken Gillman has some info on his site "Psychotropical" about combining parnate witha tricyclic, its somthing he does for resistant depression
Previous poster was right that nortriptyline (or another tricyclic) can actualy help prevent a hypertensive crisis.
The trick is to start both drugs at low doseage (say 10mg of parnate and 25mg of nortriptyline per day) and slowly increase over 2 weeks or so.
Many many patients all over the wold have been treated with this combination, if you have severe, resistant depression, its worth trying.
Posted by creepy on June 13, 2011, at 9:33:21
In reply to Parnate boosted by Desipramine, Nortryptaline, etc, posted by MRM1666 on June 4, 2011, at 8:52:21
It should be no problem adding desipramine. In fact it may help offset some of the low blood pressure issues a lot of folks get.
Nortriptyline does some work on serotonin and may be an issue.
for me, desipramine was good for fatigue. It helped with pain as well. It might make you a little anxious though. especially on top of parnate.
Wellbutrin is something else that might be added to parnate for fatigue. But if youre anxious at all that could make it worse.
Posted by MRM1666 on June 22, 2011, at 17:02:41
In reply to Re: Parnate boosted by Desipramine, Nortryptaline, etc, posted by creepy on June 13, 2011, at 9:33:21
Thank you for all of your responses.
My psychiatrist is unwilling to risk adding a TCA to the Parnate I'm on. My fatigue is such that I will have to start searching for another psychiatrist.
Thank you again.
This is the end of the thread.
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