![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by joe f on July 31, 2019, at 8:36:18
what is the sigma 1 receptor purpose as it appears that luvox is the only ssri/snri to hit that receptor .....what is its clinical significance?
Posted by linkadge on July 31, 2019, at 15:25:03
In reply to sigma 1 receptor and Luvox, posted by joe f on July 31, 2019, at 8:36:18
Fluvoxamine activates it most potently followed by citalopram and fluoxetine. It is involved in calcium homeostasis, neurogenesis and neuroprotection.
Sigma agonists, on their own, exhibit antidepressant and anti-anxiety effects. They also have the ability to improve cognition. Fluvoxamine, for instance, can reverse the cognitive impairment from a variety of drugs (like anticholinergics) while other antidepressants don't seem to do this.
The natural hormone DHEA is a sigma agonist, whereas progesterone is a sigma antagonist.
Linkadge
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.