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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Ame Sans Vie on September 16, 2003, at 13:37:00
Okay, I'm seriously giving some thought to replacing my occasional GBL use with a less... "aggressive" type of drug. I don't drink alcohol, so when I go out to have fun with friends on the weekends at the bars, I like to have a small amount of GBL -- not enough to become really intoxicated, but just enough to loosen up. Like having three or four beers.
I've done a lot of research now on tons of different GHB analogs and other interesting-sounding chemicals I could buy in bulk from an online distributor. I was just wondering if anyone had any opinions on any of these chemicals I'm about to list. I'm very well aware that I'd be taking somewhat of a risk using a research chemical like this, but they've all been used on rodents to no ill effect (unless overdosed, of course). Besides, someone has to pioneer these intriguing substances. :-)
The first twelve are GHB analogs; the rest I'll explain separately:
1. B-AL (beta-Alanine)
2. DAVA (delta-Aminovaleric acid)
3. EACT (epsilon-Aminocaproate)
4. GABBL (gamma-Amino beta-butyrolactone)
5. GABOB (gamma-Amino beta-hydroxybutanoate)
6. 2-B4O (Delta alpha,beta-Butenolide)
7. GCL (gamma-Crotonolactone)
8. GHC (gamma-Hydroxycrotonate)
9. T-HCA (trans-4,2-Hydroxycrotonic acid)
10. T-HCCA (trans-(4,4)-o-Hydroxy-chlorophenylcrotonic acid)
11. T-HNCA (trans-4-Hydroxy-4-p-nitrophenylcrotonic acid)
12. NCS-356 (4-(4-Chlorophenyl)-4-hydroxy-2-butenoic acid sodium-potassium salt)
13. TACA -- a potent agonist of GABA-c ((E)-4-Amino-2-butenoic acid)
14. SB 205384 -- GABA-a receptor modulator (4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester)
15. FAUC 73 -- selective, potent dopamine D3 receptor agonist (4-Ethynylcyclohex-3-enyl)dipropylamine)
16. Piribedil maleate -- direct dopamine agonist; selective to D3 receptor (2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine maleate salt)
17. cis(+/-)-8-OH-PBZI HBr -- selective dopamine D3 receptor agonist (cis-(±)-1,2,3a,4,5,9b-hexhydro-1H-benz[e]indole hydrobromide)
18. GR 113808 -- serotonin 5-HT4 receptor antagonist (1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate)
19. GR 127935 -- potent, selective antagonist at serotonin 5-HT1b and 5-HT1d receptors (N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2´-methyl-4´-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1´-biphenyl-4-carboxamide hydrochloride)
20. GR 46611 -- serotonin 5-HT1d receptor agonist (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
21. CP55940 -- selective cannabinoid receptor agonist (5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol)
22. CGP7930 -- positive allosteric modulator of GABA-b receptors (3-3',5'-Di-tert-butyl-4'-hydroxy)phenyl-2,2-dimethylpropanol)
23. SKF 89976A HCl -- GABA transporter type 1 (GAT-1) inhibitor that crosses the blood-brain barrier (1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride)
24. ABT-418 -- novel neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities (C9H14N2O * HCl)
25. L-655,708 -- novel ligand selective for the benzodiazepine site of GABA-a receptors which contain the alpha subunit (Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate)
26. ACEA -- potent and selective neuronal CB1 cannabinoid receptor agonist (Arachidonyl-2´-chloroethylamide)
27. ACPA -- potent and selective neuronal CB1 cannabinoid receptor agonist (Arachidonylcyclopropylamide)
28. AEA (Anandamide) -- an arachidonic acid derivative that is an endogenous ligand for the CB cannabinoid receptor and for the VR1 vanilloid receptor; inhibits calcium currents in neuroblastomas and neurons; activates the MAP kinase signaling pathway; inhibits proliferation and induces apoptosis of lymphocytes and human breast cancer cells (Arachidonylethanolamide)
29. 2-AG -- endogenous cannabinoid receptor agonist (2-Arachidonyl glycerol)
30. BML-190 -- CB2 cannabinoid receptor agonist (N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine)
31. JWH-015 -- selective CB2 cannabinoid receptor agonist (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone)
32. Linoleyl ethanolamide -- a structural analog of the endogenous cannabinoid receptor ligand anandamide
33. Mead acid ethanolamide -- agonist for CB1 and CB2 cannabinoid receptors (N-(2-Hydroxyethyl)-(Z,Z,Z)-5,8,11-eicosatrienoic acid)
34. R(+)-Methanandamide -- a congener of anandamide that is metabolically stable and displays higher affinity for the cannabinoid receptors (R(+)-Arachidonyl-1´-hydroxy-2´-propylamide)
35. O-689 -- an analog of anandamide that is a potent, selective CB1 cannabinoid receptor agonist; the methyl group at the C-2 position of arachidonic acid gives the compound enhanced metabolic stability; it can fully substitute for delta9-THC in animal self-administration tests ((+/-)-2-Methylarachidonoyl-2´-fluoroethylamide)
36. PEA -- endogenous CB2 cannabinoid receptor agonist; structural analog of anandamide (N-(2-Hydroxyethyl)hexadecanamide)
37. (R)-(+)-WIN 55,212-2 mesylate -- high affinity cannabinoid receptor agonist ((R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt)I've already tried the legal phenethylamine and tryptamine hallucinogens, so I guess that's the whole list, more or less. I'm very tempted to order a few grams of MDMA and methaquaalone though, I must admit, lol.
Posted by jparsell82 on September 26, 2003, at 12:48:56
In reply to GHB analogs, other research chemicals... opinions?, posted by Ame Sans Vie on September 16, 2003, at 13:37:00
I've tried Gamalate B6 that contains GABOB. I noticed very mild effects though. Maybe I will try a higher dosage. How does GBL compare to GHB? Also, since you've probably taken both. How do Benzos compare to GHB and it's analogs? Is the anxiolytic feeling different? Thanks.
This is the end of the thread.
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