![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by TomG on May 4, 2005, at 20:21:57
I'm interested to see if people have found one to be superior to the other.
Posted by Declan on May 5, 2005, at 1:52:31
In reply to Which Is Better? DLPA or l-phenylalanine, posted by TomG on May 4, 2005, at 20:21:57
DLPA for me because of PEA from the D form and some possible inhibition of whatever it is that breaks down endorphins and is it encephalins, also from the D form.
Declan
Posted by Sarah T. on May 5, 2005, at 2:18:14
In reply to Which Is Better? DLPA or l-phenylalanine, posted by TomG on May 4, 2005, at 20:21:57
Do you take the DLPA by itself or do you take it to augment something else?
Posted by TomG on May 5, 2005, at 13:20:45
In reply to Re: Which Is Better? DLPA or l-phenylalanine » TomG, posted by Sarah T. on May 5, 2005, at 2:18:14
I will more than likely be augmenting it with Selegiline if I use it.
Tom
Posted by Chairman_MAO on May 5, 2005, at 19:09:22
In reply to Which Is Better? DLPA or l-phenylalanine, posted by TomG on May 4, 2005, at 20:21:57
You might as well buy the racemic (DL) form, as the dextro isomer, if it does anything at all, could only help. Everyone says that it slows the breakdown of endorphins, but I'd like to see some hard evidence of that effect in man, or even in vitro with human tissue. The fact is that endorphins are broken down by a whole slew of peptidases, and not one or two enzymes like many neurotransmitters. Anyone have any good information on this?
Posted by blueberry on May 6, 2005, at 5:10:31
In reply to Which Is Better? DLPA or l-phenylalanine, posted by TomG on May 4, 2005, at 20:21:57
I think DLPA is the preferred form. I do remember seeing a clinical study where they used it to treat ADD. It was significantly effective in that study, but all the good effects were lost at 3 months. Regardless of which form you use or how well it works, tolerance may set in.
Posted by Larry Hoover on May 15, 2005, at 13:15:41
In reply to Re: Which Is Better? DLPA or l-phenylalanine » TomG, posted by Chairman_MAO on May 5, 2005, at 19:09:22
> You might as well buy the racemic (DL) form, as the dextro isomer, if it does anything at all, could only help. Everyone says that it slows the breakdown of endorphins, but I'd like to see some hard evidence of that effect in man, or even in vitro with human tissue. The fact is that endorphins are broken down by a whole slew of peptidases, and not one or two enzymes like many neurotransmitters. Anyone have any good information on this?
The data are old, and studies not well-conducted, under modern standards. Where effects were shown, they were not hugely convincing. It looks like some people have a great response, but most people have little to no response.
Animal studies focussed on carboxypeptidase A, but as you say, there are multiple pathways/enzymes to consider.
Interestingly, naloxone abolished the effect in one study.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2904213
Same folks did a different study, soon after:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1978503Whatever the mechanism might be, a lot of folks report subjective improvement from DLPA.
Lar
Posted by 4WD on May 26, 2005, at 22:50:48
In reply to Re: Which Is Better? DLPA or l-phenylalanine » Chairman_MAO, posted by Larry Hoover on May 15, 2005, at 13:15:41
Okay, so I went out and bought some DLPA. Then I read that it can exacerbate anxiety. (NE effects, presumably). I'm depressed and planning to treat this with supplements instead of the Celexa, etc. I've been on. But anxiety/fear is my big issue right now. Nortriptyline seemed to make it worse. So now I'm worried to try the DLPA. Thoughts?
Marsha
This is the end of the thread.
Psycho-Babble Alternative | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.