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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on October 29, 2005, at 16:15:59
I've been reading a number of studies on depression possably being linked to bad a tryptophan hydroxylase gene.
Can somebody explain to me what is bypassed by taking 5-htp over tryptophan? Is tryptohpan hydroxylase needed after 5-htp ?
Linkadge
Posted by Larry Hoover on October 30, 2005, at 7:28:07
In reply to Does 5-htp bypass tryptophan hydroxylase ?, posted by linkadge on October 29, 2005, at 16:15:59
> I've been reading a number of studies on depression possably being linked to bad a tryptophan hydroxylase gene.
>
> Can somebody explain to me what is bypassed by taking 5-htp over tryptophan? Is tryptohpan hydroxylase needed after 5-htp ?
>
> Linkadge5-HTP is the product of tryptophan hydroxylase. Ergo, if one is deficient in that enzyme, 5-HTP is the stuff to take.
The only problem is, the next step is much less specific and unique. 5-HTP is converted to serotonin by decarboxylase, and those enzymes are ubiquitous.
The way the healthy body ensures that serotonin is only produced where it is needed is by localizing tryptophan hydroxylase. Oral 5-HTP tends to promote serotonin formation wherever the blood happens to take it.
Lar
Posted by linkadge on October 30, 2005, at 9:19:59
In reply to Re: Does 5-htp bypass tryptophan hydroxylase ? » linkadge, posted by Larry Hoover on October 30, 2005, at 7:28:07
If only they actually knew what was wrong with the depressed brain. The serotonin transporter has been studied for a while, but the genetic testing is all coming out negative.
Infact the most depressed people seem to have the short-short varient of the transporter gene, which actually codes for a slower reuptake of serotoin, than in their non-depressed counterparts.
What are you taking these days? (If you don't mind me asking)Linkadge
Posted by teejay on October 30, 2005, at 17:21:42
In reply to Re: Does 5-htp bypass tryptophan hydroxylase ? » linkadge, posted by Larry Hoover on October 30, 2005, at 7:28:07
Hi Larry, nice to see you around these parts again :-)
Posted by Larry Hoover on December 4, 2005, at 19:54:21
In reply to Re: Does 5-htp bypass tryptophan hydroxylase ?, posted by linkadge on October 30, 2005, at 9:19:59
> What are you taking these days? (If you don't mind me asking)
>
> LinkadgeSorry, if you were talking to me. Nothing, from a mood perspective. I'm caught up in pain treatment, and I'm doing multiple med trials there. I've stopped everything else to avoid confounds.
Lar
This is the end of the thread.
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