![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Linzie on September 13, 2003, at 0:04:17
so, granted i shouldnt do e on perscription drugs, but the past few times since ive been on abilify, esctasy does NOTHING to me, and gets all my friends fucked up.... is there some weird combo thing going on? anyone?
thanks!
Posted by stjames on September 13, 2003, at 0:35:33
In reply to E and Abilify, posted by Linzie on September 13, 2003, at 0:04:17
Many AD's and other psycomeds block e.
So stop spending your monry on e.
Posted by Dr. Bob on September 13, 2003, at 14:43:59
In reply to E and Abilify, posted by Linzie on September 13, 2003, at 0:04:17
> esctasy does NOTHING to me, and gets all my friends f*cked up....
Sorry to be such a prude, but I need to ask you please not to use language that could offend others, thanks.
Bob
Posted by djmmm on September 14, 2003, at 7:59:02
In reply to E and Abilify, posted by Linzie on September 13, 2003, at 0:04:17
> so, granted i shouldnt do e on perscription drugs, but the past few times since ive been on abilify, esctasy does NOTHING to me, and gets all my friends fucked up.... is there some weird combo thing going on? anyone?
>
> thanks!Yeah..I would say that combining the two creates a mess of pharmacological interactions...it's best to avoid E while on any other psychoactive meds (antidepressants or otherwise)...MDMA has a variety of actions in your brian, effecting various neurotransmitters, as does Abilify...
As to why you aren't "feeling" the effects, this is partially due to Abilify competitivly blocking the specific (most likely serotonin) receptors that MDMA utilizes. SSRI users (specifically the more potent SSRIs) also experience an attenuated or completely abolished high when they take MDMA.
From personal experience, in the long run, taking E isn't worth it.
Posted by Sebastian on September 14, 2003, at 10:23:33
In reply to Re: E and Abilify, posted by djmmm on September 14, 2003, at 7:59:02
Maybe you have been doing too much E? If you do it close toggether it does not have the same effect.
Posted by djmmm on September 14, 2003, at 12:20:27
In reply to Re: E and Abilify, posted by Sebastian on September 14, 2003, at 10:23:33
> Maybe you have been doing too much E? If you do it close toggether it does not have the same effect.
Im certain her "problem" has more to do with the interaction of both drugs at serotonin receptors (specifically 5ht-1A) and Abilify's moderate affinity for the serotonin reuptake pump, which MDMA competes for.
Even mild SSRIs like trazadone, and drugs that have very little to no effect of the serotonin system (Wellbutrin) can attenuate the positive "empathetic" qualities unique to MDMA
This is the end of the thread.
Psycho-Babble Substance Use | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.