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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Tom Twilight on February 25, 2007, at 14:38:12
Cannabis really calms me down!
It works better than an a Benzo for me
Question is why does it work so well?I've heard that Cannabis reduces Cortropin releasing factor, is this why it helps?
Or is this one of multiple actions?
Posted by dbc on February 25, 2007, at 14:38:12
In reply to Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 10:10:55
Not to be rude but can we not have this conversation on this board because its on every board. Theres constantly people touting how wonderful pot is for psychiatric disorders.
Posted by Jimmyboy on February 25, 2007, at 14:38:12
In reply to Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 10:10:55
I would also like to know what it does in your brain.. I have times where I think its helpful and times where I think its helpful , and sometimes very harmful. It probably just depends on my state of the mind at the time I used it.
JB
Posted by Larry Hoover on February 25, 2007, at 14:38:13
In reply to Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 10:10:55
> Cannabis really calms me down!
>
> It works better than an a Benzo for me
> Question is why does it work so well?
>
> I've heard that Cannabis reduces Cortropin releasing factor, is this why it helps?
> Or is this one of multiple actions?One of multiple actions, without doubt.
We (in our typical human arrogance) have labelled certain receptors in the brain as cannabinoid receptors. Well, it turns out that Mamma Nature had other ideas in mind as to what they are for. It turns out that these receptors respond to a chemical called anandamide (after the Sanskrit word for bliss). And other natural ligands, too. Once you're into multiple receptors and multiple ligands, it gets very complicated, very fast. So, I'll just leave it at that.
New theories about what might be "remedied" by marijuana include:
http://www.nel.edu/pdf_/25_12/NEL251204R02_Russo_.pdf
http://www.biopsychiatry.com/endocannabinoid.htm
http://www.psych.ubc.ca/~bglab/neuro.htmlThe key with cannabis, I think, is to find a method of employing the beneficial properties, while avoiding the adverse ones, i.e. do not smoke this stuff. Vapourizers are an option. All sorts of oral preps, too. Smoking it, though, deteriorates lung function greater than that caused by tobacco.
Lar
Posted by Chairman_MAO on February 25, 2007, at 14:38:13
In reply to Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 10:10:55
There are myriad mechanisms of action. Indeed, one is inhibition of CRF release (unfortunately, this comes surging back after you stop). Another is potentiation of mu-1 opioid activity (mu-2 are the ones in the brainstem that cause respiratory depression); THC is an indirect mu-opioid agonist.
Cannabis also can increase melatonin levels up to ~1000%; this is not necessarily a good thing, but it does help sleep.
I look at cannabis as nature's cold/flu tonic: kills pain, but you still can feel it enough to take care of yourself; it quells nausea, makes food taste better, eases anxiety, makes you want to drink water, etc. Of course, this is only one of probably thousands of legitimate uses of it, which is one of the primary reasons it's illegal, of course.
Posted by Tom Twilight on February 25, 2007, at 14:38:13
In reply to Re: Cannabis-Why do I respond well?, posted by dbc on February 21, 2007, at 11:51:06
Thanks all
I guess Cannabis is a very complicated drug!
It could be all sorts of things in Cannabis that might be helping me.
Maybe its the MU thing rather than Cortropin-its a bit worrying how Cortropin rebounds after use!Someone implied that I was saying Cannabis was great for mental health.
Look I'm not saying that!It can have terrible affects for some people, we're all different!
Posted by linkadge on February 25, 2007, at 14:38:13
In reply to Re: Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 13:11:58
Know yourself and know your sources.
Drugs do not fall into categories of black or white. Hopefully research will continue on the application of purified constituents of marajuanna to certain neurological disorders.
The university I am attending currently, for instance, is reseaching the application of marajuanna constutuents to parkinsons disease.
Linkadge
Posted by Chairman_MAO on February 25, 2007, at 14:38:13
In reply to Re: Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 13:11:58
It can be great for mental health, but for most people, memory problems are an issue.
Posted by scratchpad on February 25, 2007, at 14:38:13
In reply to Re: Cannabis-Why do I respond well? » Tom Twilight, posted by Larry Hoover on February 21, 2007, at 12:10:58
Great links, Lar. Thanks for that!
I vapourize and my lungs thank me with every breath.Scratch
Posted by Declan on February 25, 2007, at 14:38:13
In reply to Re: Cannabis-Why do I respond well? » Tom Twilight, posted by Chairman_MAO on February 21, 2007, at 12:47:27
>Cannabis also can increase melatonin levels up to ~1000%; this is not necessarily a good thing, but it does help sleep.<
I had my melatonin levels tested after cannabis and the result was greater than 500, the target range being 35
Posted by laima on February 25, 2007, at 14:38:13
In reply to Cannabis and Melatonin, posted by Declan on February 21, 2007, at 16:56:08
What! Is that good or bad then? Was that while pretty stoned, or later?
> >Cannabis also can increase melatonin levels up to ~1000%; this is not necessarily a good thing, but it does help sleep.<
>
> I had my melatonin levels tested after cannabis and the result was greater than 500, the target range being 35
Posted by Phillipa on February 25, 2007, at 14:38:13
In reply to Re: Cannabis and Melatonin » Declan, posted by laima on February 21, 2007, at 20:21:40
I've never used it in any way. Love Phillipa
Posted by TheMeanReds on February 25, 2007, at 14:38:13
In reply to Cannabis-Why do I respond well?, posted by Tom Twilight on February 21, 2007, at 10:10:55
I call my klonopin 'my weed pill' to stoners I know. haha
Posted by Declan on February 25, 2007, at 14:38:14
In reply to Re: Cannabis and Melatonin » Declan, posted by laima on February 21, 2007, at 20:21:40
That was an hour or two after.
I wasn't very stoned....just a bit over a threshold dose.
I dunno if it's good or bad.
(I was responding to Chairman Mao's post about melatonin and marijuana.)
This is the end of the thread.
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