Posted by shellie on November 29, 2000, at 13:11:53
In reply to Re: Serzone side effects - just temporary?, posted by dove on November 29, 2000, at 11:18:23
Scott and Dove.
What I was talking about here was the effect of what has been called "poop-out". I was on nardil for about eight years, then it was no longer effective. After being off for several months I went back on with renewed effectiveness; then about five years later nardil lost its effectiveness again and this time a break does not reproduce it's original effectiveness. I go for a consultation with a psychopharmacolgist and he says this is quite common--the tendency for anti-depressants, to lose effectiveness over time.
I have not had a lot of time to look on the internet; it does not seem to be a very researched topic, or else I am putting in the wrong key words.
I guess I thought this was popular knowledge because of the many many people on the board who have used a specific antidepressant successfully, only to have it die on them. So maybe you guys are reading something it to my statement that I had not intended.
And I've thought of the concept of perhaps if I had not stayed on the nardil for so long originally, I could have bought myself more time later for success on it. (I think, perhaps that was what you were thinking about in the shower, Scott).
My sister had to double her dose of prozac after about six years to get the same effect--there might be some info on increasing same medication to maintain the same effect, which may be related to the idea of an antidepressant losing effectiveness. Perhaps if I was able to double nardil, that would have done the trick, but side effects eliminated that possibility. I didn't start out as treatment resistent; my life didn't take an unexpected bad turn. I've always assumed it had to do with the development of tolerance toward a medication. This has also made me a skeptic when it comes to finding the right cocktail for me--if found, how do I know how long will it remain effective for me.
Anyway, are these the ideas you are talking about, or are you extrapolating something else from what I said?
later, and later, Shellie
poster:shellie
thread:49361
URL: http://www.dr-bob.org/babble/20001115/msgs/49634.html