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Re: Selegiline Combos: Andrew

Posted by Lorraine on March 16, 2001, at 11:21:40

In reply to Re: Selegiline Combos: Lorraine, posted by AndrewB on March 15, 2001, at 10:21:57

{Anyway since amphetamine can cause anxiety, and the MAO-B inhibition is what results in the desired effect from low dose selegiline, taking a lower dose may be produce noticeably less anxiety but have the same positive effect on motivation and vitality. I take 5mg./day.}

You may be right about the lower dosage. I started with the lower dosage but moved up because it was not "supporting" me--but I was also on a low dose of Neurontin. Now I'm at 900 mg Neurontin and getting some mood support from it, I may be able to scale back the Selegiline. I'll try 7.5 and take it from there good tip. My anxiety, by the way, is purely physical--tightness in chest, difficultly taking in a deep breath, I've been trying Magnesium, Taurine and thinking about adding GABA to try to get it under control. I don't think that I could have done the Selegiline without the Neurotin, but with the two my physical anxiety is not worse than it was before the Selegiline, it just isn't better. I may need to add a beta blocker ultimately. The thing is I am able to function for the first time in a long time. My pdoc also said that I could add dexedrine to my Neurontin/Selegiline combo if I want. If scaling back the Selegiline doesn't work, I may try scaling back and adding 2.5 dexidrine to the mix. For some reason, dexidrine doesn't seem to worsen my anxiety symptoms. I'm just not clear which Dopamine receptors are being hit by the Selegiline and which would be hit by the dexedrine. I know that with Mirapex its D2 and D3, with the emphasis strongly on the D3 (8 to 1 or something like that). Thanx for the post.


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