Posted by Elizabeth on July 22, 2001, at 12:31:24
In reply to Re: Moclobemide » Elizabeth, posted by Neal on July 22, 2001, at 0:05:33
> BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
>
> I'm sorry to hear that, since moclobemide dosen't have any food restrictions. Why is it not a viable substitute?The list of foods that you actually need to avoid is pretty minimal -- I can post if you like. (I took MAOIs for the better part of 5 years -- at various times, Nardil, Parnate, Marplan, and selegiline -- so I've made a point of doing my research.)
Moclobemide's reputation is that it just doesn't have the same efficacy as Nardil or Parnate in treatment-resistant depression, although because of its safety profile and relative ease of use it can be a first- or second-line treatment for depression and some anxiety disorders.
Of course, Nardil and Parnate aren't really identical either. Nardil has more of an anxiolytic effect (IMO; there are pharmacological reasons why this would be the case), while Parnate has more of a stimulant-type effect (the pharmacological reason hasn't been determined; there isn't much research being done anymore on these old drugs).
-elizabeth
poster:Elizabeth
thread:71256
URL: http://www.dr-bob.org/babble/20010720/msgs/71358.html