Posted by adamie on September 8, 2001, at 10:49:00
In reply to any serotonine enhancers intolerance, possible ?, posted by Sigolène on September 8, 2001, at 3:28:21
> No psychiatrist wants to believe me when i say I'm a complete serotonine enhancers intolerant. No matter which way the med. acts, i'm even intolerant to natural products like plants wich have a very small effect on serotonine. I also can't tolerate lithium because it acts on serotonine. I need a very specific norepinephrine active med, wich is not easy to find.
> All serotonine meds are worsening my depression very fast (3rd day), and there is no ulterior improvement.
>
> When I say this to any psychiatrist, they answer that if serotonine enhancers could worsen depression, it should be known for a long time, and they never heard about that. They think this king of remark is due to my "personality disorder", which makes my incapable of objective judgment... I hate hearing things like that.
>
> I think that if there is no research reporting complete intolerance to serotonine enhancers, it's because it's against the interests of medication industry, which finances nearly all med. researchers.
>
> If anyone of you knows even one research reporting about that intolerance effect on 5HT enhancers, I would really appreciate that you gave me the reference of it, in order to show it to those narrow minded psychiatrists. Thank you.
> And if you are like me, complete serotonine enhancers intolerant, I would be glad to know you, so please answer to that message. I'll know then that i'm not alone against medications industry.
>
> Sigolènehi. i have had a very similar problem. all seratonin meds have made me worse. on paxil I didn't notice it enough at first because I was completely horrible before starting it, but 24 days into it I was convinced it was making me worse. I just felt very very bad. I stopped and 3-4 days after there was a miracle improvement. I was so naturally living life again, but not quite my normal self yet, but at least things were enjoyable. this lasted for 1 week then it got worse and i just really wanted to try another med. I was put on effexor. On the first day I noticed it was making me feel very detached and just worse. but i thought that would pass. it didn't. the 2nd day wasn't too bad but then the 3rd and following because progressively horrible. I felt suicidal. The constant mind torture was too much. I stopped the med and 3 days later I was better but I was put on another med before I could recover from the effexor. this time i was put on zyprexa along with wellbutrin. this combo is supossed to work for only a small portion of seratonin, most dopamine and norepinephrine. at first i didn't feel really worse. i guess i was recovering from the effexor. then after my mood was just getting steadily worse. not a good sign. so i stopped that also and just went on 5htp. after 3 days i was slightly better. 5 days after i was even better. There were moments where I could enjoy things a bit. And no mind torture!
so i was off meds and just on 5htp for 10 days. i tried adding st john's wort to it because i read how it enhances 5htp. the first two doses in the day i didn't feel a noticable worsening effect. but then after the 3rd dose i felt like i was losing my mind. like i was going phychotic or something. then strangely i was feeling a bit better afterwards. so i thought i might as well try it again. the next day i just felt kind of worse in general. so i stopped that. just 5htp then.
i dont know if the 5htp was helping me but at least i felt not bad enough to stop it. so i stayed on it for those 12 days or so. what i felt it may have been helping me with was my appetite. I had a pretty big appetite on the 5htp. I dunno what else it was helping me with. 5htp is supossed to increase levels of seratonin, norepinephrine, and dopamine. perhaps i didn't feel worse or just not notice being worse (perhaps I would have been better off it) because perhaps seratonin reuptake inhibiting is bad for me. but not the actual increasing of seratonin. Something those meds did was making me worse.
My depression has been caused by accutane. So basically my brain has had excess vitamin A and it hasn't gone away yet. Somehow the meds for my specific case made me worse. also when my depression is worse the sides of my head feel very very hot. and it would also feel very tight. like my brain was expanding or something.
the last med i have tried was prozac. This too made me worse. much worse. this morning and yesterday have been HELL. and the first day I tried the prozac I was feeling completely horrible for like 4 hours. Enough to want to be hospitalized. It passed but the next few days I just have been progressively much worse than when I was off prozac. It hasn't become as bas as those 4 completely horrible hours but close to it. expecially this morning. almost constant mind torture in bed. I know it's the prozac. No doubt about it. so i will recover from this worsening effect in the next 3-5 days. Aside from the large worsening effect I have also lost most of my appetite, yesterday I hardly ate anything. Also a lot of insomnia. Normally I have slept far too well with this depression. More than when I was my normal perfectly happy self. because I would always think of things and have a big imagination. i liked that about me. so i had trouble sleeping normally. the depression has made me brain dead. so sleeping became kind of easy. with the prozac not only was my thinking ability worse, but also i could hardly sleep at all. the mind torture would make sleeping difficult.
I will try other meds later on. maybe something will not make me worse and i'll be able to keep on taking it to see if it makes me better.
regarding doctors. the one at the hospital too didn't believe me when I told him of the worsening effects of the meds. He said it was impossible. What he deserves is a slap in the face. I know how they make me feel. In the end he didn't take me seriously and even told me he thinks I have some normalicy in mood. I wish. The only time I felt near normal was that miracle period after stopping paxil. take care.
poster:adamie
thread:78234
URL: http://www.dr-bob.org/babble/20010907/msgs/78259.html